Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 14653..15179 Replicon plasmid pA_F11
Accession NZ_CP092902
Organism Klebsiella pneumoniae strain F11

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag F11wdg_RS25780 Protein ID WP_000323025.1
Coordinates 14892..15179 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag F11wdg_RS25775 Protein ID WP_000534858.1
Coordinates 14653..14892 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F11wdg_RS25750 (F11wdg_pA0013) 10651..11991 + 1341 WP_000589001.1 ISNCY family transposase -
F11wdg_RS25755 (F11wdg_pA0014) 12412..12723 + 312 Protein_10 transposase -
F11wdg_RS25765 (F11wdg_pA0017) 13974..14390 + 417 Protein_12 cation transporter dimerization domain-containing protein -
F11wdg_RS25770 14524..14628 - 105 Protein_13 protein YdfV -
F11wdg_RS25775 (F11wdg_pA0018) 14653..14892 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
F11wdg_RS25780 (F11wdg_pA0019) 14892..15179 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
F11wdg_RS25785 (F11wdg_pA0020) 15251..15409 + 159 WP_004181898.1 type I toxin-antitoxin system Hok family toxin -
F11wdg_RS25790 (F11wdg_pA0021) 16012..16986 + 975 WP_004181899.1 hypothetical protein -
F11wdg_RS25795 (F11wdg_pA0022) 17184..17561 - 378 WP_004181901.1 hypothetical protein -
F11wdg_RS25800 (F11wdg_pA0023) 18251..19318 + 1068 WP_004181903.1 hypothetical protein -
F11wdg_RS25805 (F11wdg_pA0024) 19474..19821 + 348 WP_004181904.1 hypothetical protein -
F11wdg_RS25810 (F11wdg_pA0025) 19900..20133 + 234 WP_004181905.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaCTX-M-14 / qacE / catB3 / blaOXA-1 / fosE - 1..221757 221757


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T237353 WP_000323025.1 NZ_CP092902:14892-15179 [Klebsiella pneumoniae]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T237353 NZ_LR881938:c4563334-4562993 [Escherichia coli str. K-12 substr. MG1655]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT237353 WP_000534858.1 NZ_CP092902:14653-14892 [Klebsiella pneumoniae]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT237353 NZ_LR881938:4563329-4563405 [Escherichia coli str. K-12 substr. MG1655]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References