Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4691618..4692134 Replicon chromosome
Accession NZ_CP092901
Organism Klebsiella pneumoniae strain F11

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag F11wdg_RS22915 Protein ID WP_004178374.1
Coordinates 4691618..4691902 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag F11wdg_RS22920 Protein ID WP_002886901.1
Coordinates 4691892..4692134 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
F11wdg_RS22890 (4687013) 4687013..4687321 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
F11wdg_RS22895 (4687406) 4687406..4687579 + 174 WP_032412860.1 hypothetical protein -
F11wdg_RS22900 (4687582) 4687582..4688325 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
F11wdg_RS22905 (4688682) 4688682..4690820 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
F11wdg_RS22910 (4691150) 4691150..4691614 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
F11wdg_RS22915 (4691618) 4691618..4691902 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
F11wdg_RS22920 (4691892) 4691892..4692134 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
F11wdg_RS22925 (4692212) 4692212..4694122 - 1911 WP_004152270.1 PRD domain-containing protein -
F11wdg_RS22930 (4694145) 4694145..4695299 - 1155 WP_002886900.1 lactonase family protein -
F11wdg_RS22935 (4695366) 4695366..4696106 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T237349 WP_004178374.1 NZ_CP092901:c4691902-4691618 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T237349 NZ_LR881938:c3683579-3683472 [Escherichia coli str. K-12 substr. MG1655]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT237349 WP_002886901.1 NZ_CP092901:c4692134-4691892 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT237349 NZ_LR881938:3683628-3683694 [Escherichia coli str. K-12 substr. MG1655]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References