Detailed information of TA system TA237346

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2704089..2705677
• Replicon: chromosome
• Accession: NZ_CP092901
• Organism: Klebsiella pneumoniae strain F11

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: F11wdg_RS13465
• Protein ID: WP_064151580.1
• Coordinates: 2704089..2705411 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: F11wdg_RS13470
• Protein ID: WP_004176198.1
• Coordinates: 2705411..2705677 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
F11wdg_RS13450 (2699145)	2699145..2701646	+	2502	WP_064151582.1	fimbria/pilus outer membrane usher protein	-
F11wdg_RS13455 (2701634)	2701634..2702638	+	1005	WP_064151581.1	fimbrial protein	-
F11wdg_RS13460 (2702780)	2702780..2704072	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
F11wdg_RS13465 (2704089)	2704089..2705411	-	1323	WP_064151580.1	type II toxin-antitoxin system HipA family toxin	Toxin
F11wdg_RS13470 (2705411)	2705411..2705677	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
F11wdg_RS13475 (2705943)	2705943..2706269	-	327	WP_004176200.1	hydroxyisourate hydrolase	-
F11wdg_RS13480 (2706266)	2706266..2706766	-	501	WP_064151579.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
F11wdg_RS13485 (2706744)	2706744..2708123	-	1380	WP_213075714.1	nucleobase:cation symporter-2 family protein	-
F11wdg_RS13490 (2708469)	2708469..2709623	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
F11wdg_RS13495 (2709604)	2709604..2710527	-	924	WP_008804925.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T237346 WP_064151580.1 NZ_CP092901:c2705411-2704089 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
AHSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T237346 NZ_LR881938:c3152035-3151739 [Escherichia coli str. K-12 substr. MG1655]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT237346 WP_004176198.1 NZ_CP092901:c2705677-2705411 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT237346 NZ_LR881938:c3151737-3151342 [Escherichia coli str. K-12 substr. MG1655]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA