Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 496298..496892 Replicon chromosome
Accession NZ_CP092892
Organism Agrobacterium tumefaciens strain LN-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag MLE07_RS02430 Protein ID WP_243016359.1
Coordinates 496578..496892 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MLE07_RS02425 Protein ID WP_107675227.1
Coordinates 496298..496597 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLE07_RS02400 (MLE07_02400) 491486..492484 + 999 WP_243016357.1 asparaginase -
MLE07_RS02405 (MLE07_02405) 492619..493239 + 621 WP_078051121.1 glutathione S-transferase family protein -
MLE07_RS02410 (MLE07_02410) 493333..493992 - 660 WP_003508979.1 glutathione S-transferase family protein -
MLE07_RS02415 (MLE07_02415) 494075..494590 - 516 WP_099085580.1 MarR family transcriptional regulator -
MLE07_RS02420 (MLE07_02420) 494732..496261 + 1530 WP_060723904.1 MDR family MFS transporter -
MLE07_RS02425 (MLE07_02425) 496298..496597 - 300 WP_107675227.1 putative addiction module antidote protein Antitoxin
MLE07_RS02430 (MLE07_02430) 496578..496892 - 315 WP_243016359.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MLE07_RS02435 (MLE07_02435) 497123..498139 + 1017 WP_187772749.1 ligase-associated DNA damage response exonuclease -
MLE07_RS02440 (MLE07_02440) 498141..499766 + 1626 WP_243016361.1 cisplatin damage response ATP-dependent DNA ligase -
MLE07_RS02445 (MLE07_02445) 499941..500906 + 966 WP_107675229.1 alpha/beta fold hydrolase -
MLE07_RS02450 (MLE07_02450) 500945..501727 - 783 WP_243016362.1 glycosyltransferase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(6-97)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11871.61 Da        Isoelectric Point: 10.5742

>T237331 WP_243016359.1 NZ_CP092892:c496892-496578 [Agrobacterium tumefaciens]
MNSFQKSAEFDEWLKVLKDRAGKVRILHRLTAAEHGNFGDCAPVGEGVSEMRIHFGPGYRVYFTRVGKRVYFLLVGGDKS
SQRRDIKRAIEMAQTIGRDGRDRI

Download         Length: 315 bp

>T237331 NZ_LR881938:c1268499-1268392 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10737.28 Da        Isoelectric Point: 4.8307

>AT237331 WP_107675227.1 NZ_CP092892:c496597-496298 [Agrobacterium tumefaciens]
MAVTEFSKFDVSDYLDSDEAMIEFLAIAMEDENPDVFIGALGAVAKARGMSHIADASGLGRESLYKALRPGSKLRYETVQ
KVLHALGFRLAVEKSLNAA

Download         Length: 300 bp

>AT237331 NZ_LR881938:1268547-1268613 [Escherichia coli str. K-12 substr. MG1655]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References