Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 3597449..3598065 Replicon chromosome
Accession NZ_CP092891
Organism Microbacterium oxydans strain ML-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MME74_RS17390 Protein ID WP_267416369.1
Coordinates 3597449..3597850 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MME74_RS17395 Protein ID WP_267416370.1
Coordinates 3597847..3598065 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MME74_RS17370 (MME74_17350) 3593613..3594578 - 966 WP_267418607.1 alpha-ketoacid dehydrogenase subunit beta -
MME74_RS17375 (MME74_17355) 3594590..3595732 - 1143 WP_267416366.1 thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha -
MME74_RS17380 (MME74_17360) 3595849..3596916 - 1068 WP_267416367.1 histidinol-phosphate transaminase -
MME74_RS17385 (MME74_17365) 3597036..3597440 + 405 WP_267416368.1 phage holin family protein -
MME74_RS17390 (MME74_17370) 3597449..3597850 - 402 WP_267416369.1 PIN domain nuclease Toxin
MME74_RS17395 (MME74_17375) 3597847..3598065 - 219 WP_267416370.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MME74_RS17400 (MME74_17380) 3598110..3599426 - 1317 WP_267416371.1 hypothetical protein -
MME74_RS17405 (MME74_17385) 3599423..3599686 - 264 WP_267416372.1 hypothetical protein -
MME74_RS17410 (MME74_17390) 3599896..3600345 + 450 WP_267418609.1 low molecular weight protein-tyrosine-phosphatase -
MME74_RS17415 (MME74_17395) 3600369..3601751 + 1383 WP_267418610.1 adenylosuccinate lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-120)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-41)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14261.36 Da        Isoelectric Point: 4.2778

>T237328 WP_267416369.1 NZ_CP092891:c3597850-3597449 [Microbacterium oxydans]
VILVDTSVWIAYLRGTDSPAAEQLNGLIAEGADLAITEPVIMELLAGAARPRERARVEVLTNGLPLIGIDPVGDFRDAAD
LYRASALNGHPIRSMTDCLIAAVAIRSDVALLHGDRDFEFLAEVSPLRLCPTE

Download         Length: 402 bp

>T237328 NZ_LR881938:252301-252699 [Escherichia coli str. K-12 substr. MG1655]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8093.20 Da        Isoelectric Point: 4.5600

>AT237328 WP_267416370.1 NZ_CP092891:c3598065-3597847 [Microbacterium oxydans]
MARTNIDIDEDLVREVMRRYSLSTKKEAVDLALRRLVGVPLTKEFLLGLRGTGWSGDLDAMRDDAPASWGDE

Download         Length: 219 bp

>AT237328 NZ_LR881938:252005-252298 [Escherichia coli str. K-12 substr. MG1655]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References