Detailed information of TA system TA237327

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-pasA/RelE-HTH
• Location: 1987892..1988381
• Replicon: chromosome
• Accession: NZ_CP092888
• Organism: Bifidobacterium sp. FKU

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MMB48_RS08995
• Protein ID: WP_229773994.1
• Coordinates: 1987892..1988119 (-)
• Length: 76 a.a.

Antitoxin (Protein)

• Gene name: pasA
• Uniprot ID: A0A4V2N072
• Locus tag: MMB48_RS09000
• Protein ID: WP_032744823.1
• Coordinates: 1988145..1988381 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMB48_RS08980 (MMB48_08935)	1985115..1985837	-	723	WP_032744819.1	hypothetical protein	-
MMB48_RS08985 (MMB48_08940)	1985902..1986858	-	957	WP_032744820.1	A/G-specific adenine glycosylase	-
MMB48_RS08990 (MMB48_08945)	1986879..1987541	+	663	WP_136527151.1	tRNA (cytidine(34)-2'-O)-methyltransferase	-
MMB48_RS08995 (MMB48_08950)	1987892..1988119	-	228	WP_229773994.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMB48_RS09000 (MMB48_08955)	1988145..1988381	-	237	WP_032744823.1	ribbon-helix-helix domain-containing protein	Antitoxin
MMB48_RS09005 (MMB48_08960)	1988964..1989677	-	714	WP_080714860.1	4'-phosphopantetheinyl transferase superfamily protein	-
MMB48_RS09010 (MMB48_08965)	1989688..1991013	-	1326	WP_230581269.1	MFS transporter	-
MMB48_RS09015 (MMB48_08970)	1991040..1992227	-	1188	WP_032744825.1	carboxylate--amine ligase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1987892..1997225	9333

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-72)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 76 a.a.
• Molecular weight: 8653.22 Da
• Isoelectric Point: 10.1818

>T237327 WP_229773994.1 NZ_CP092888:c1988119-1987892 [Bifidobacterium sp. FKU]
MKKLDRNVAKRIIAKLREISQLEDPRSTGKALAGNLAGLWRYRVGDYRIVCDIEDEVLLILVIDVAHRSKVYKRC

Nucleotide

• Length: 228 bp

>T237327 NZ_LR881938:c246239-245961 [Escherichia coli str. K-12 substr. MG1655]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8928.15 Da
• Isoelectric Point: 4.2821

>AT237327 WP_032744823.1 NZ_CP092888:c1988381-1988145 [Bifidobacterium sp. FKU]
MATVTAALRMPVELAARYDCLAKATGRTKTFYMNEALTESIDRFEYEYGIMKKVEDWRAGRLETVTLDELEESLGLED

Nucleotide

• Length: 237 bp

>AT237327 NZ_LR881938:c246502-246242 [Escherichia coli str. K-12 substr. MG1655]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: A0A4V2N072