Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 1133688..1134541 Replicon chromosome
Accession NZ_CP092888
Organism Bifidobacterium sp. FKU

Toxin (Protein)


Gene name relE Uniprot ID A0A7D5BU34
Locus tag MMB48_RS04970 Protein ID WP_032745209.1
Coordinates 1134050..1134541 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8G4I4
Locus tag MMB48_RS04965 Protein ID WP_011068030.1
Coordinates 1133688..1134050 (+) Length 121 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB48_RS04960 (MMB48_04945) 1130843..1133542 + 2700 WP_032745210.1 aconitate hydratase AcnA -
MMB48_RS04965 (MMB48_04950) 1133688..1134050 + 363 WP_011068030.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MMB48_RS04970 (MMB48_04955) 1134050..1134541 + 492 WP_032745209.1 PIN domain-containing protein Toxin
MMB48_RS04975 (MMB48_04960) 1134602..1136706 - 2105 Protein_964 DUF262 domain-containing protein -
MMB48_RS04980 (MMB48_04965) 1136795..1137436 - 642 WP_032745208.1 GNAT family N-acetyltransferase -
MMB48_RS04985 (MMB48_04970) 1137477..1137617 - 141 Protein_966 LuxR C-terminal-related transcriptional regulator -
MMB48_RS04990 (MMB48_04975) 1137786..1138688 + 903 WP_032745207.1 Bax inhibitor-1/YccA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-141)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-53)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18298.86 Da        Isoelectric Point: 4.5590

>T237324 WP_032745209.1 NZ_CP092888:1134050-1134541 [Bifidobacterium sp. FKU]
MTDVSMQRILLDTNVLLDYLLHRDDHAKMAEAVMELGAKNNVTLLCASLSLKDIAYLSSSAIRRECKPNESEVENFTRGF
LSSRVPWRCIEQVKEMCDIVAVDESTCDKAFSLQKRHRDFEDDLIIVAAQQSGANCVVTSDAELISHFPEYCRTPAEIVA
ALE

Download         Length: 492 bp

>T237324 NZ_LR881936:c2774084-2773982 [Enterobacter cancerogenus]
GCAAGGCGATTGAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 121 a.a.        Molecular weight: 14004.05 Da        Isoelectric Point: 5.0733

>AT237324 WP_011068030.1 NZ_CP092888:1133688-1134050 [Bifidobacterium sp. FKU]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREEEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDKMYDEQLDTYYNMKRAD

Download         Length: 363 bp

>AT237324 NZ_LR881936:2773978-2774120 [Enterobacter cancerogenus]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTCAATCGCCTTGCACTTTAAGAATAGATGACGACGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7D5BU34

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2W1N3

References