Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-DinJ
Location 15070..15635 Replicon chromosome
Accession NZ_CP092888
Organism Bifidobacterium sp. FKU

Toxin (Protein)


Gene name relE Uniprot ID A0A0M4LG91
Locus tag MMB48_RS00055 Protein ID WP_060620320.1
Coordinates 15070..15360 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A7D5CUA8
Locus tag MMB48_RS00060 Protein ID WP_032743427.1
Coordinates 15357..15635 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB48_RS00035 (MMB48_00035) 10279..10845 + 567 WP_032743433.1 DUF3566 domain-containing protein -
MMB48_RS00040 (MMB48_00040) 11491..12912 + 1422 WP_032743432.1 ATP-binding protein -
MMB48_RS00045 (MMB48_00045) 12973..13197 - 225 WP_032743431.1 substrate-binding domain-containing protein -
MMB48_RS00050 (MMB48_00050) 13346..14692 - 1347 WP_032743429.1 NADP-specific glutamate dehydrogenase -
MMB48_RS00055 (MMB48_00055) 15070..15360 - 291 WP_060620320.1 type II toxin-antitoxin system YafQ family toxin Toxin
MMB48_RS00060 (MMB48_00060) 15357..15635 - 279 WP_032743427.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MMB48_RS00065 16108..16335 - 228 WP_212105774.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
MMB48_RS00070 (MMB48_00070) 16438..17082 + 645 WP_032743426.1 hypothetical protein -
MMB48_RS00075 (MMB48_00075) 17504..17695 - 192 WP_032743423.1 hypothetical protein -
MMB48_RS00090 (MMB48_00090) 19170..20432 - 1263 WP_032743422.1 metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(6-95)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10839.54 Da        Isoelectric Point: 9.9591

>T237322 WP_060620320.1 NZ_CP092888:c15360-15070 [Bifidobacterium sp. FKU]
MSGIQYTVKTTSRFRKDFKLARRRGLDAGLFKQVVSILSEGGTLPDRYHDHALTGNMTGFRECHITPDLLLVYLIEKDVL
VLTLTRTGTHSDLFGK

Download         Length: 291 bp

>T237322 NZ_LR881936:c1135032-1134814 [Enterobacter cancerogenus]
ATGTCTGAAAAACCATTAACCAAGATCGATTATTTGATGCGCTTGCGGCGTTGTCAGTCACTGGACACGCTTGAACGTGT
TATCGAAAAAAATAAATATGAGCTTTCTGATAACGAACTGGCTGTATTTTACTCAGCAGCGGATCATCGCCTGGCCGAGT
TAACCATGAATAAGCTTTACGACAAAATACCGTCTTCCGTATGGAAATTTGTCCGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10274.69 Da        Isoelectric Point: 5.1231

>AT237322 WP_032743427.1 NZ_CP092888:c15635-15357 [Bifidobacterium sp. FKU]
MSGTTTTVNVRMNAELKKQAEELFEELGMNLTTAVNIFIRQSLRQGGIPFNVSLDEPNRETVSAMLEAKRIARDGNVKGY
RDLNALFKDLDA

Download         Length: 279 bp

>AT237322 NZ_LR881936:c1135434-1135060 [Enterobacter cancerogenus]
ATGGACGAGTACTCGCCAAAAAGGCATGATATTGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGTCTTGC
CAATCTTGATGAAAGTAACCATGGGTGGGTTAACGACCCCACCTCGGCCATCAATTTGCAGCTTAATGAACTGATAGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGCTGATTGAGCAAATTGATGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTACGGCATTAACGCCCAGGATTTGCAGAAATGGCGTAAATCAGGAAATCGGCT
ATTCCGTTGTTTCATCAATGCAAGTCGAGCTAATCCTGTTAGCCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4LG91

Antitoxin

Source ID Structure
AlphaFold DB A0A7D5CUA8

References