Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 226021..226556 Replicon plasmid unnamed
Accession NZ_CP092862
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MLB75_RS26295 Protein ID WP_154074340.1
Coordinates 226269..226556 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MLB75_RS26290 Protein ID WP_154074341.1
Coordinates 226021..226272 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS26275 (MLB75_26275) 223916..224518 - 603 WP_277399502.1 IS110 family transposase -
MLB75_RS26280 (MLB75_26280) 224585..224772 + 188 Protein_207 IS3 family transposase -
MLB75_RS26285 (MLB75_26285) 225219..225464 + 246 Protein_208 helix-turn-helix transcriptional regulator -
MLB75_RS26290 (MLB75_26290) 226021..226272 + 252 WP_154074341.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MLB75_RS26295 (MLB75_26295) 226269..226556 + 288 WP_154074340.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MLB75_RS26300 (MLB75_26300) 226562..226927 + 366 WP_241066525.1 hypothetical protein -
MLB75_RS26305 (MLB75_26305) 226924..227205 + 282 WP_241066527.1 hypothetical protein -
MLB75_RS26310 (MLB75_26310) 227219..227446 + 228 WP_277399501.1 hypothetical protein -
MLB75_RS26315 (MLB75_26315) 227498..228457 + 960 WP_241066528.1 VirK/YbjX family protein -
MLB75_RS26320 (MLB75_26320) 228535..229512 + 978 WP_241066592.1 lauroyl-Kdo(2)-lipid IV(A) myristoyltransferase -
MLB75_RS26325 (MLB75_26325) 229623..229960 - 338 Protein_216 DDE-type integrase/transposase/recombinase -
MLB75_RS26330 (MLB75_26330) 229993..230148 - 156 Protein_217 IS3 family transposase -
MLB75_RS26335 (MLB75_26335) 230140..230214 - 75 Protein_218 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iucA / iucB / iucC / iucD / iutA / ybtS / ybtX / ybtQ / ybtP / ybtE 1..246756 246756
- flank IS/Tn - - 229623..229754 131


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11156.25 Da        Isoelectric Point: 10.6254

>T237321 WP_154074340.1 NZ_CP092862:226269-226556 [Salmonella enterica]
MTYIVRFREDALKEWQKLDKAIQRQFAKKLKKCCENPHIPSAKLRGIKDCYKIKLRASGFRLVYQVIDAQLIIAVVAVGK
RERSDVYNLASERMR

Download         Length: 288 bp

>T237321 NZ_LR881936:c645934-645413 [Enterobacter cancerogenus]
GTGAACGATGTGAAGATAGGGATTTTTTCAGAAGACGTTGAGTACGACCTGAGCCAGTTCGATTGCGGAGAAGTAAGCCT
TAACACCTTCCTTGCAGAACACCTTAAACGCCAGCATCGCGGGAAGTTTTTGCGTGCCTACGTTCTCACGACCCGCGAGG
AAAACCCGCGAGTTCTGGGTTATTACACGCTCTCCGGGAGTTGCTTTGAAAAAGCTTACCTGCCCTCTAAAACTCAGCAG
AAGCGCATTCCTTATAAAAATGTGCCGAGCGTAACCTTAGGGCGTCTGGCTATTGATAAACGCATTCAGGGGCAAGGTTT
TGGTGAGTTACTTGTCACCCATGCTATGAAGACCGTCTATTTGGCCTCCTTTGCCGTCGGCATTCATGGTCTGTTTGTTG
AAGCGCTGAACGATACAGCCAGAAATTTTTACCTCAAACTGGGGTTCATACCGCTTCTGGCCGAGAATGAATTCACGCTC
TTCTTACCGACGAAAACCTTTGAAAGCATGTTTGAAGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9254.52 Da        Isoelectric Point: 4.1265

>AT237321 WP_154074341.1 NZ_CP092862:226021-226272 [Salmonella enterica]
MPNIILSDTSASVSELKKNPMAIVSAGDGYPVAILNRNQPAFYCVPAELYEKMLDALDDQELVKLIDERSNQKLHDVDLD
SYL

Download         Length: 252 bp

>AT237321 NZ_LR881936:c646207-645938 [Enterobacter cancerogenus]
ATGACAGCACTGAAGAAACAGCGCATCGATCTGAGGTTAAGCGAAGACGATAAAAGCCTGATCGAAGAAGCTGCAGCAAT
GACCAACCAGTCAATTTCGCAGTTCATGGTCAGCACGGCTTCTGAACGCGCTGCGGAAGTTATCGATCGACACCGTCGCA
TGATCCTTAATGAAGCCTCCTGGAATACGGTAATGGAGGCCATCAGCAACCCGCCGGCACCAAATGACCGCCTGAAACGC
GCGGCGAAGCGTCTCCAGGATATGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References