Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 177605..178158 Replicon plasmid unnamed
Accession NZ_CP092862
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag MLB75_RS26120 Protein ID WP_154074328.1
Coordinates 177605..177919 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag MLB75_RS26125 Protein ID WP_241066515.1
Coordinates 177922..178158 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS26090 (MLB75_26090) 172814..172954 - 141 WP_241066513.1 hypothetical protein -
MLB75_RS26095 (MLB75_26095) 173092..173478 - 387 WP_241066514.1 conjugal transfer relaxosome DNA-binding protein TraM -
MLB75_RS26100 (MLB75_26100) 173902..174411 + 510 WP_154074371.1 transglycosylase SLT domain-containing protein -
MLB75_RS26105 (MLB75_26105) 174717..175462 - 746 Protein_172 DUF932 domain-containing protein -
MLB75_RS26115 (MLB75_26115) 177059..177217 - 159 Protein_174 LysR family transcriptional regulator -
MLB75_RS26120 (MLB75_26120) 177605..177919 - 315 WP_154074328.1 CcdB family protein Toxin
MLB75_RS26125 (MLB75_26125) 177922..178158 - 237 WP_241066515.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MLB75_RS26130 (MLB75_26130) 179013..179693 - 681 WP_154074329.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - iucA / iucB / iucC / iucD / iutA / ybtS / ybtX / ybtQ / ybtP / ybtE 1..246756 246756


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11691.73 Da        Isoelectric Point: 7.9875

>T237320 WP_154074328.1 NZ_CP092862:c177919-177605 [Salmonella enterica]
MQFTVYRNTGKIVAYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGAARPERMIPIIRLTDGREYAVMTHELASIPIRALG
AEFCDAAQYRTQIKAAIDFLFDGI

Download         Length: 315 bp

>T237320 NZ_LR881936:621233-621607 [Enterobacter cancerogenus]
ATGCAAACCATATCATCACACCTGACACGGGCGGCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGTTGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTGATGAAACCACCATCCAGAAACATATTG
ATGCAGGAATATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGATAAGAATTGACCGCGATGGTTGC
TCTGTCATGGCGCAGAAGTCACCGTTTATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACG
CAGCAGTCACAAAACTGTTACCAGGGCAACGGCAGGCCAACATCAGGAGCTATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8817.77 Da        Isoelectric Point: 6.2182

>AT237320 WP_241066515.1 NZ_CP092862:c178158-177922 [Salmonella enterica]
VTAKQRNTQSVTVTVERGLLSLAREAGINLSATLTAALDAELREHATRKWQEKNTEALEALNRFHDEHGCFSDEYRTF

Download         Length: 237 bp

>AT237320 NZ_LR881936:620829-621194 [Enterobacter cancerogenus]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCCAGCAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTGCTTTCA
GCGACGAGCATGCGTTGCGCCTAGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGTTGATGCTCACCAGCGGAGAG
CTCAACCCTAGGCACCCGCACAGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTTCATTGCTATCTATCCTGAGCAGACTGAACCGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References