Detailed information of TA system TA237320

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 177605..178158
• Replicon: plasmid unnamed
• Accession: NZ_CP092862
• Organism: Salmonella enterica strain P164045

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: MLB75_RS26120
• Protein ID: WP_154074328.1
• Coordinates: 177605..177919 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: MLB75_RS26125
• Protein ID: WP_241066515.1
• Coordinates: 177922..178158 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLB75_RS26090 (MLB75_26090)	172814..172954	-	141	WP_241066513.1	hypothetical protein	-
MLB75_RS26095 (MLB75_26095)	173092..173478	-	387	WP_241066514.1	conjugal transfer relaxosome DNA-binding protein TraM	-
MLB75_RS26100 (MLB75_26100)	173902..174411	+	510	WP_154074371.1	transglycosylase SLT domain-containing protein	-
MLB75_RS26105 (MLB75_26105)	174717..175462	-	746	Protein_172	DUF932 domain-containing protein	-
MLB75_RS26115 (MLB75_26115)	177059..177217	-	159	Protein_174	LysR family transcriptional regulator	-
MLB75_RS26120 (MLB75_26120)	177605..177919	-	315	WP_154074328.1	CcdB family protein	Toxin
MLB75_RS26125 (MLB75_26125)	177922..178158	-	237	WP_241066515.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
MLB75_RS26130 (MLB75_26130)	179013..179693	-	681	WP_154074329.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	iucA / iucB / iucC / iucD / iutA / ybtS / ybtX / ybtQ / ybtP / ybtE	1..246756	246756

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11691.73 Da
• Isoelectric Point: 7.9875

>T237320 WP_154074328.1 NZ_CP092862:c177919-177605 [Salmonella enterica]
MQFTVYRNTGKIVAYPLLLDVTSDIIGQLNRRVVIPLLPVEKYPGAARPERMIPIIRLTDGREYAVMTHELASIPIRALG
AEFCDAAQYRTQIKAAIDFLFDGI

Nucleotide

• Length: 315 bp

>T237320 NZ_LR881936:621233-621607 [Enterobacter cancerogenus]
ATGCAAACCATATCATCACACCTGACACGGGCGGCTCAGCCCTGCCTGTCACCCGTTGAAATCTGGCAGTTGCTGCTGAC
TCATCTGTTATCGCAGCACTATGGCCTGACGCTGAATGACACACCGTTCAGTGATGAAACCACCATCCAGAAACATATTG
ATGCAGGAATATCGCTCAGCGATGCGGTGAACTTTCTTGTCGAAAAATATGAACTGATAAGAATTGACCGCGATGGTTGC
TCTGTCATGGCGCAGAAGTCACCGTTTATCACCAGTATCGATATTCTACGTGCCCGGAAAGCCTCCGGTCTGATGAAACG
CAGCAGTCACAAAACTGTTACCAGGGCAACGGCAGGCCAACATCAGGAGCTATAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8817.77 Da
• Isoelectric Point: 6.2182

>AT237320 WP_241066515.1 NZ_CP092862:c178158-177922 [Salmonella enterica]
VTAKQRNTQSVTVTVERGLLSLAREAGINLSATLTAALDAELREHATRKWQEKNTEALEALNRFHDEHGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT237320 NZ_LR881936:620829-621194 [Enterobacter cancerogenus]
ATGAACAATCACTCAGAATCCGGTGCCATACCGGAGAATCCCCCCTGCCAGCAGTGGGGGCTAAAGAGTACGATCACACC
CTGTTTTGGAGCTCGGCTGGTGCAAGAAGGCGACCGCCTGCATTTTCTCGCTGACCGCGCCGGGTTTAACGGTGCTTTCA
GCGACGAGCATGCGTTGCGCCTAGACCAGGCCTTTCCGTTGATACTCAAGCAGCTGGAGTTGATGCTCACCAGCGGAGAG
CTCAACCCTAGGCACCCGCACAGCGTCACGCTTTACCACAACGGACTCACCTGCGAAGCCGACACACTCGGCTCCTGTGG
CTATGTCTTCATTGCTATCTATCCTGAGCAGACTGAACCGCAGTAA