Detailed information of TA system TA237319

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 147494..148119
• Replicon: plasmid unnamed
• Accession: NZ_CP092862
• Organism: Salmonella enterica strain P164045

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MLB75_RS25940
• Protein ID: WP_154074294.1
• Coordinates: 147721..148119 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MLB75_RS25935
• Protein ID: WP_195183092.1
• Coordinates: 147494..147721 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLB75_RS25935 (MLB75_25935)	147494..147721	+	228	WP_195183092.1	toxin-antitoxin system antitoxin VapB	Antitoxin
MLB75_RS25940 (MLB75_25940)	147721..148119	+	399	WP_154074294.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MLB75_RS25945 (MLB75_25945)	148128..150284	-	2157	WP_241066484.1	type IV conjugative transfer system coupling protein TraD	-
MLB75_RS25950 (MLB75_25950)	150650..151381	-	732	WP_241066486.1	conjugal transfer complement resistance protein TraT	-
MLB75_RS25955 (MLB75_25955)	151480..151791	+	312	WP_241066487.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	iucA / iucB / iucC / iucD / iutA / ybtS / ybtX / ybtQ / ybtP / ybtE	1..246756	246756

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-125)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14901.11 Da
• Isoelectric Point: 7.8604

>T237319 WP_154074294.1 NZ_CP092862:147721-148119 [Salmonella enterica]
MLKFMLDTNICIFTIKNKPASVRERFNLNQGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLDVLDYDPAAATHT
GQIRADLARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVDGLRTEDWS

Nucleotide

• Length: 399 bp

>T237319 NZ_LR881936:546730-547023 [Enterobacter cancerogenus]
ATGACTTATGAACTGGAATTCGACCCGAGGGCATTAAAGGAGGGGCGTAAACTGGGCGATACCGTAAAAGCCCAGTTTAA
GAAGAAGTTAGCCAGCGTACTGGTGAATCCCCGGAATGAATCTGCCCGCCTGCATGACCTGCATGACCTGCCTGACTGCT
ACAAGATAAAGCTTAAATCCTCTGGCTACCGCCTGGTTTATCAGGTGCGGGACGCGGTGGTTATTGTTTTTGTCATTTCC
ATTGGTAAGCGAGAGAAATCCGCTGCGTATCAGGCCGCAAGCAAACGGCTTTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8523.52 Da
• Isoelectric Point: 4.5358

>AT237319 WP_195183092.1 NZ_CP092862:147494-147721 [Salmonella enterica]
METSVFLSNRSQAVRLPKAVALPENVKRVEIIAVGRTRIITPAGESWDEWFDGNNVSADFMDNREQPSVQERESF

Nucleotide

• Length: 228 bp

>AT237319 NZ_LR881936:546498-546740 [Enterobacter cancerogenus]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTTAAAAACGAGGCGTATGCCGTGCTGGAAAAACTCAATATCACCCC
CACTGAAGCGGTACGGCTACTGTTTCAGTACGTTGCAGAGACCGGACGGATGCCGGTGAAAACTGTCACCATAAGCGACG
GTGAAGAGGCGCTTATTCAGACAGTCCGGGAGCGACTGGCTAATCCACAAAAGGGAATTAAGGTTAGTCTGGATGACTTA
TGA