Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 132453..133123 | Replicon | plasmid unnamed |
| Accession | NZ_CP092862 | ||
| Organism | Salmonella enterica strain P164045 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | MLB75_RS25860 | Protein ID | WP_154074368.1 |
| Coordinates | 132453..132869 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | - |
| Locus tag | MLB75_RS25865 | Protein ID | WP_154074260.1 |
| Coordinates | 132893..133123 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MLB75_RS25830 (MLB75_25830) | 127761..128042 | - | 282 | WP_241066480.1 | helix-turn-helix transcriptional regulator | - |
| MLB75_RS25835 (MLB75_25835) | 128023..128352 | - | 330 | WP_080861456.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| MLB75_RS25840 (MLB75_25840) | 128536..128784 | - | 249 | Protein_119 | Rpn family recombination-promoting nuclease/putative transposase | - |
| MLB75_RS25845 (MLB75_25845) | 129117..130688 | - | 1572 | WP_241065574.1 | IS66 family transposase | - |
| MLB75_RS25850 (MLB75_25850) | 130708..131055 | - | 348 | WP_001406649.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| MLB75_RS25855 (MLB75_25855) | 131055..131702 | - | 648 | WP_241065573.1 | IS66-like element accessory protein TnpA | - |
| MLB75_RS25860 (MLB75_25860) | 132453..132869 | - | 417 | WP_154074368.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MLB75_RS25865 (MLB75_25865) | 132893..133123 | - | 231 | WP_154074260.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MLB75_RS25870 (MLB75_25870) | 133768..134724 | + | 957 | WP_154074272.1 | hypothetical protein | - |
| MLB75_RS25875 (MLB75_25875) | 134725..135036 | + | 312 | WP_154074273.1 | cytoplasmic protein | - |
| MLB75_RS25880 (MLB75_25880) | 135026..135817 | + | 792 | WP_154074274.1 | site-specific integrase | - |
| MLB75_RS25885 (MLB75_25885) | 136217..136576 | + | 360 | Protein_128 | IS110 family transposase | - |
| MLB75_RS25890 (MLB75_25890) | 136623..136859 | + | 237 | Protein_129 | IS110 family transposase | - |
| MLB75_RS25895 (MLB75_25895) | 137008..137379 | + | 372 | WP_241066481.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | iucA / iucB / iucC / iucD / iutA / ybtS / ybtX / ybtQ / ybtP / ybtE | 1..246756 | 246756 | |
| - | inside | IScluster/Tn | - | - | 126448..140029 | 13581 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15043.46 Da Isoelectric Point: 7.2156
>T237318 WP_154074368.1 NZ_CP092862:c132869-132453 [Salmonella enterica]
MLDTCICSFIMREQPAAVIKRLEQAVLRNHRIVVSAITYAEMRFGATGPKASPRHIALVDAFCARLDAILPWDRAAVDAT
TEIKVALRQTGTPIGPNDTAIAGHAMAVGAILVTNNTREFERVPELSLEDWVKYAGAL
MLDTCICSFIMREQPAAVIKRLEQAVLRNHRIVVSAITYAEMRFGATGPKASPRHIALVDAFCARLDAILPWDRAAVDAT
TEIKVALRQTGTPIGPNDTAIAGHAMAVGAILVTNNTREFERVPELSLEDWVKYAGAL
Download Length: 417 bp
>T237318 NZ_LR881936:50778-51176 [Enterobacter cancerogenus]
ATGCGGCATATGCTGGACACCAATATGGTTAGCCATCTCGTACGGCAACATCCTGAGGTGGTGAGCCAGTATTCGAAAAT
TGCACCGGATGACATGTGTATTTCAAGCGTAACGGAGGCGGAATTACTTTATGGCGTAGCCAAAAAGCATAGCCCTAAAC
TCAAAGAAACCATTCTGGAATTTCTCAAAACCATCACCGTCTGCGACTGGGACAGCGAGGCCGCAACCACCTACGGCGCG
CTCCGTGCGGCGATGGAAAAGAGAGGCAACGTCATGGGCGATCTCGACCAGCTGATCGCTGCGCATGCCATCAGCCAGGG
CACCACCATTGTCACGAACGATCGTGCTTTTCTGATGGTGCAGGAGTTAAGCGTGGAAGACTGGACGCACGCTGCCTGA
ATGCGGCATATGCTGGACACCAATATGGTTAGCCATCTCGTACGGCAACATCCTGAGGTGGTGAGCCAGTATTCGAAAAT
TGCACCGGATGACATGTGTATTTCAAGCGTAACGGAGGCGGAATTACTTTATGGCGTAGCCAAAAAGCATAGCCCTAAAC
TCAAAGAAACCATTCTGGAATTTCTCAAAACCATCACCGTCTGCGACTGGGACAGCGAGGCCGCAACCACCTACGGCGCG
CTCCGTGCGGCGATGGAAAAGAGAGGCAACGTCATGGGCGATCTCGACCAGCTGATCGCTGCGCATGCCATCAGCCAGGG
CACCACCATTGTCACGAACGATCGTGCTTTTCTGATGGTGCAGGAGTTAAGCGTGGAAGACTGGACGCACGCTGCCTGA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8712.77 Da Isoelectric Point: 4.2803
>AT237318 WP_154074260.1 NZ_CP092862:c133123-132893 [Salmonella enterica]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAELEKADADFMVEREDVVSDEGRFDL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAELEKADADFMVEREDVVSDEGRFDL
Download Length: 231 bp
>AT237318 NZ_LR881936:50515-50775 [Enterobacter cancerogenus]
ATGGAACACAAAGCAAAACTGTTTAAAAGAGGGCGAAGCCAGGCGGTAATGCTGCCTGCTGAATTTACGTTTGATGCGGA
GAGTGTTTATATCCGGCGGGATGACGACGGGAATGTGGTGCTGACGGCTATTTCAGAGAAAGCGCGACACAGAGAAATCT
TTTTGCGTTTACTCAAGCAAACGCCGGTGCCGGATTCCTTCCTTAGCAAAGAGGAGCGTAATCAGAGCTATACGTCCAGG
GATCCGTTAGAAGGGTTATAG
ATGGAACACAAAGCAAAACTGTTTAAAAGAGGGCGAAGCCAGGCGGTAATGCTGCCTGCTGAATTTACGTTTGATGCGGA
GAGTGTTTATATCCGGCGGGATGACGACGGGAATGTGGTGCTGACGGCTATTTCAGAGAAAGCGCGACACAGAGAAATCT
TTTTGCGTTTACTCAAGCAAACGCCGGTGCCGGATTCCTTCCTTAGCAAAGAGGAGCGTAATCAGAGCTATACGTCCAGG
GATCCGTTAGAAGGGTTATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|