Detailed information of TA system TA237313

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 4382634..4383161
• Replicon: chromosome
• Accession: NZ_CP092861
• Organism: Salmonella enterica strain P164045

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5W8C7J3
• Locus tag: MLB75_RS21980
• Protein ID: WP_000409331.1
• Coordinates: 4382634..4382909 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MLB75_RS21985
• Protein ID: WP_241065875.1
• Coordinates: 4382913..4383161 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLB75_RS21945 (4378047)	4378047..4378322	+	276	WP_001074456.1	transcriptional regulator	-
MLB75_RS21950 (4378435)	4378435..4378569	+	135	Protein_4306	PTS glucitol/sorbitol transporter subunit IIC	-
MLB75_RS21955 (4378582)	4378582..4379166	+	585	Protein_4307	Gfo/Idh/MocA family oxidoreductase	-
MLB75_RS21960 (4379202)	4379202..4379747	-	546	WP_000718702.1	hypothetical protein	-
MLB75_RS21965 (4379762)	4379762..4380802	-	1041	WP_000617193.1	ParB/Srx family N-terminal domain-containing protein	-
MLB75_RS21970 (4380984)	4380984..4381163	-	180	WP_229023603.1	Arm DNA-binding domain-containing protein	-
MLB75_RS21975 (4381720)	4381720..4382517	-	798	WP_241065874.1	helix-turn-helix transcriptional regulator	-
MLB75_RS21980 (4382634)	4382634..4382909	-	276	WP_000409331.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MLB75_RS21985 (4382913)	4382913..4383161	-	249	WP_241065875.1	ribbon-helix-helix domain-containing protein	Antitoxin
MLB75_RS21990 (4383238)	4383238..4384071	-	834	WP_198871409.1	DUF4942 domain-containing protein	-
MLB75_RS21995 (4384187)	4384187..4384528	-	342	WP_001194750.1	TA system toxin CbtA family protein	-
MLB75_RS22000 (4384572)	4384572..4384913	-	342	WP_000380486.1	type IV toxin-antitoxin system YeeU family antitoxin	-
MLB75_RS22005 (4385016)	4385016..4385843	+	828	WP_223164635.1	5'-nucleotidase	-
MLB75_RS22010 (4385921)	4385921..4386796	-	876	WP_000135476.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-42)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 11072.40 Da
• Isoelectric Point: 4.8783

>T237313 WP_000409331.1 NZ_CP092861:c4382909-4382634 [Salmonella enterica]
MEIYWTLKAQDDLERIYRFALQYSRQHADDVLDRLITGCADLTAHPAIGVQQTRYEPRQVRKVLFDDYEVHYELRDNDIY
IVDLWHTKEER

Nucleotide

• Length: 276 bp

>T237313 NZ_LR881934:c4519021-4518680 [Citrobacter freundii]
ATGAATACTTTACCTGTAATAAACCAGCGGGCTGTTCAGTCATGCCCATCGCCCGTAACTATCTGGCAAACGTTGCTAAC
TCGTTTACTGGAACAACACTACGGGTTGGCGCTGAACGACACACCATTTGGTAATGAAAGCGTCATTCAGGAACATATCG
AGGCCGGTATTACGCTCGTTGATGCCGTTAATTTCTTGGTGGAAAAGTACGAGTTGGCTCGTATCGACCGCAGGGTGTTT
AGCTGGCTGGAACCATCTCCATACTTGCGAGCTGTAGACATTCTGCGAGCGCGCCGGGACACAGGGTTGTTGCGAGGATG
CAATCACACTGTTGCACCGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8960.26 Da
• Isoelectric Point: 7.2045

>AT237313 WP_241065875.1 NZ_CP092861:c4383161-4382913 [Salmonella enterica]
MASSAKQTISAQIPVELAAAVENLAIELDRSKSWIIKEALTSMLAERERRHQSIQAGLADVDAGRVVSHSEMVDFANRLK
KA

Nucleotide

• Length: 249 bp

>AT237313 NZ_LR881934:c4519386-4519057 [Citrobacter freundii]
ATGAATGACGATACTGCCGAGCCCTGGTGGGGCTTGAGTTGTAACGCCATCCCTTGTTTTGGTGCACGTCTGGTCCAGGA
AGGTAATCGCCTACATTATCTGGCTGACCGCGCCAGCATAATAGGTCAGTTCAATGAAGCGGATTTAATCCATCTTGATC
AGGCATTCCCGGTACTGCTGAAACAGGTGGAGCTCATGCTTACCAACGGCAAACTGAATCCCCGACACCAGCATTGCGTC
ACGCTCTATGCAAATGGGTTGACCTGCGAAGCTGATACGCTGGGTTCCTGTGGCCACGTCTATATTGCCATTTACCTTAC
TCAACGCTAA

Structures

Toxin

• AlphaFold DB: A0A5W8C7J3