Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3740142..3740762 Replicon chromosome
Accession NZ_CP092861
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MLB75_RS18985 Protein ID WP_001280991.1
Coordinates 3740544..3740762 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MLB75_RS18980 Protein ID WP_000344807.1
Coordinates 3740142..3740516 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS18970 (3735281) 3735281..3736474 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MLB75_RS18975 (3736497) 3736497..3739646 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MLB75_RS18980 (3740142) 3740142..3740516 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MLB75_RS18985 (3740544) 3740544..3740762 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MLB75_RS18990 (3740941) 3740941..3741492 + 552 WP_001278793.1 maltose O-acetyltransferase -
MLB75_RS18995 (3741609) 3741609..3742079 + 471 WP_000136183.1 YlaC family protein -
MLB75_RS19000 (3742135) 3742135..3742275 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MLB75_RS19005 (3742281) 3742281..3742541 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MLB75_RS19010 (3742766) 3742766..3744316 + 1551 WP_241065783.1 EAL domain-containing protein -
MLB75_RS19020 (3744547) 3744547..3744936 + 390 WP_000961285.1 MGMT family protein -
MLB75_RS19025 (3744969) 3744969..3745538 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T237312 WP_001280991.1 NZ_CP092861:3740544-3740762 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T237312 NZ_LR881934:3872455-3872673 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATCCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT237312 WP_000344807.1 NZ_CP092861:3740142-3740516 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT237312 NZ_LR881934:3872053-3872427 [Citrobacter freundii]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAATTTCTCTGCGAAACTCTGTATCATGACTGTCTTGC
AAACCTTGAACAAAGTAACCATGGCTGGGTTAATGACCCTACCTCTGCAACCAGCTTGCAGCTCAATGAACTGATAGAGC
ATATTGCAACCTTCGCACTTAATTATAAAATTAAGTACAATGAGGACAATAAGCTGATCGCGCAGATAGATGAATACCTG
GATGACACTTTTATGTTGTTCAGCAGTTATGGTATTAATACGCAGGATCTGCAGAAATGGCGGAAGTCAGGTAATCGACT
GTTTCGCTGTTTTGTCAATGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References