237303

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2470868..2471390 Replicon chromosome
Accession NZ_CP092861
Organism Salmonella enterica strain P164045

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MLB75_RS12415 Protein ID WP_000221343.1
Coordinates 2470868..2471152 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MLB75_RS12420 Protein ID WP_000885424.1
Coordinates 2471142..2471390 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLB75_RS12395 (2466943) 2466943..2468451 - 1509 WP_241066383.1 FAD-dependent oxidoreductase -
MLB75_RS12400 (2468496) 2468496..2468984 + 489 WP_023194239.1 MarR family winged helix-turn-helix transcriptional regulator -
MLB75_RS12405 (2469177) 2469177..2470256 + 1080 WP_241066384.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MLB75_RS12410 (2470308) 2470308..2470697 - 390 WP_076933590.1 RidA family protein -
MLB75_RS12415 (2470868) 2470868..2471152 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MLB75_RS12420 (2471142) 2471142..2471390 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MLB75_RS12425 (2471542) 2471542..2471757 + 216 WP_000206207.1 hypothetical protein -
MLB75_RS12430 (2471747) 2471747..2472079 + 333 WP_000253158.1 DUF1493 family protein -
MLB75_RS12435 (2472230) 2472230..2472520 + 291 Protein_2440 hypothetical protein -
MLB75_RS12440 (2472594) 2472594..2473762 + 1169 WP_241065557.1 IS3-like element IS911 family transposase -
MLB75_RS12445 (2473773) 2473773..2474250 + 478 Protein_2442 hypothetical protein -
MLB75_RS12450 (2474306) 2474306..2475040 - 735 Protein_2443 helix-turn-helix domain-containing protein -
MLB75_RS12455 (2475547) 2475547..2475633 - 87 Protein_2444 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T237303 WP_000221343.1 NZ_CP092861:c2471152-2470868 [Salmonella enterica]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T237303 NZ_LR881183:971913-972308 [Thermococcus camini]
ATGGTAATTGATGCCTCTGTCCTAGCCAAATACGTTCTCCTCGAACCTGGCTGGGAACGGATCGAGGAGCTACTCCTGAA
AGATGTCGTCTCGCTTGACTACGCCTTGGCTGAGGTTTCAAACGCCCTCTGGAAACATCACGTCCTCTACGGAAGAATCT
CACGGGAGGAATTCGAAAAACGGGTGCTTGTGGTTGACGCAGTACCTAATGTGGTCATTCTGGAAAGTGGACTACAGTAT
CTTCATCACGCGAAGAGCATAGCCTTGGAGCACAGAATCACCGTTTATGACGCCCTCTACATCGCTCAGGCCCTGAAGTA
TGGCGAACTTGCCACCAGTGACAAAGAGCAGGGAAAAATAGCGGAGAAACTCGGCGTTGAGGTAACCTACCTCTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT237303 WP_000885424.1 NZ_CP092861:c2471390-2471142 [Salmonella enterica]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT237303 NZ_LR881183:971702-971923 [Thermococcus camini]
ATGGCGGTCATAAGCGTTCGCGTCCCGGACGAGCTAAAGGAGAAGATGAAGAAGTACGACATCAACTGGAGCGAGGAGAT
ACGGCGGTTCATAGCTTCGAGAATAAGCAAGGAGGAGAAGAGAAGAACCGTTGAGATGATGCACGAGTTACTCGCTGGGG
GAATCCCCGCTAAGGAAGGAACCGCAAAAAGGTACGTGAGGGAGGACCGTGATGGTAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References