Detailed information of TA system TA237301

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 895989..896614
• Replicon: chromosome
• Accession: NZ_CP092861
• Organism: Salmonella enterica strain P164045

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MLB75_RS04425
• Protein ID: WP_000911337.1
• Coordinates: 896216..896614 (+)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: C0PXM4
• Locus tag: MLB75_RS04420
• Protein ID: WP_000557545.1
• Coordinates: 895989..896216 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLB75_RS04390 (891034)	891034..892551	+	1518	WP_000003339.1	lysine--tRNA ligase	-
MLB75_RS04395 (892627)	892627..893172	-	546	WP_000133986.1	isopentenyl-diphosphate Delta-isomerase	-
MLB75_RS04400 (893437)	893437..894195	+	759	WP_000244328.1	amidase activator ActS	-
MLB75_RS04410 (894480)	894480..895286	-	807	WP_010989071.1	DUF1460 domain-containing protein	-
MLB75_RS04415 (895561)	895561..895812	-	252	WP_001540858.1	hypothetical protein	-
MLB75_RS04420 (895989)	895989..896216	+	228	WP_000557545.1	toxin-antitoxin system antitoxin VapB	Antitoxin
MLB75_RS04425 (896216)	896216..896614	+	399	WP_000911337.1	tRNA(fMet)-specific endonuclease VapC	Toxin
MLB75_RS04430 (897417)	897417..897953	+	537	WP_001038500.1	STM3031 family outer membrane protein	-
MLB75_RS04435 (898000)	898000..898632	+	633	WP_052932722.1	YfdX family protein	-
MLB75_RS04440 (899360)	899360..899941	+	582	WP_241066110.1	fimbrial protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	894480..904413	9933

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 15037.43 Da
• Isoelectric Point: 7.7785

>T237301 WP_000911337.1 NZ_CP092861:896216-896614 [Salmonella enterica]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Nucleotide

• Length: 399 bp

>T237301 NZ_LR880474:359323-359586 [Microbacterium sp. Nx66]
GTGACGCGGTACCGCGTCGAGTTCACCACCGCAGCGGCGAAGGAGGTCCGCAAGCTGGATCCTCCGCTCCGTCGGCGCAT
CCTCGCCGGGATCTCCGACCTCGAACGGGAGCCTCGTCCGCACGGCGTCCGCAAGCTCGCCGGGTTCGACAACGCCTGGC
GCGTGCGGATCGGCGACTACCGTGTGCTCTACGAGGTCGTGGACGAGCGGGTGCTCGTCACCGTGGTCCGCGTCGCCCAC
CGGCGGGACGTCTACGACCTCTGA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8500.48 Da
• Isoelectric Point: 5.0053

>AT237301 WP_000557545.1 NZ_CP092861:895989-896216 [Salmonella enterica]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Nucleotide

• Length: 228 bp

>AT237301 NZ_LR880474:359066-359326 [Microbacterium sp. Nx66]
ATGAACACTCTCAGCCGCAGCGTGCCGTCGAAGGACCTGCGCGATCAGCTCGCCGACGTTCTCGGCGGTGTCGCGTACGG
GGCGGAGCGGGTGGGGGTGACGCGTCACGGCAAGCTCACCGCGGTCGTGATCGGCGTCGACGATCTCGAGCTCCTGGAAG
AGCTCGAGGCTGCGCGAGATGCGGCGGAGTTCGGAGCGGCGAAGGCGGCGGACGACGGGGGTCGAGTCTCGCTCGATGAC
CTCCGTGCGGAACTCCCGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0R9MGW6