Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3869057..3869677 Replicon chromosome
Accession NZ_CP092860
Organism Citrobacter braakii strain P1

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MJ613_RS19180 Protein ID WP_002892050.1
Coordinates 3869459..3869677 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag MJ613_RS19175 Protein ID WP_019076175.1
Coordinates 3869057..3869431 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ613_RS19165 (MJ613_19155) 3864204..3865397 + 1194 WP_185654229.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MJ613_RS19170 (MJ613_19160) 3865420..3868569 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
MJ613_RS19175 (MJ613_19165) 3869057..3869431 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
MJ613_RS19180 (MJ613_19170) 3869459..3869677 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MJ613_RS19185 (MJ613_19175) 3869858..3870409 + 552 WP_185654228.1 maltose O-acetyltransferase -
MJ613_RS19190 (MJ613_19180) 3870526..3870996 + 471 WP_047416865.1 YlaC family protein -
MJ613_RS19195 (MJ613_19185) 3871075..3871215 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
MJ613_RS19200 (MJ613_19190) 3871217..3871477 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
MJ613_RS19205 (MJ613_19195) 3871666..3873219 + 1554 WP_185654227.1 EAL domain-containing protein -
MJ613_RS19210 (MJ613_19200) 3873271..3873624 - 354 WP_003831033.1 DUF1428 family protein -
MJ613_RS19215 (MJ613_19205) 3873689..3874318 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T237296 WP_002892050.1 NZ_CP092860:3869459-3869677 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T237296 NZ_LR878366:46721-47203 [Shigella flexneri 3a]
ATGGAAATAAATGTCACCGCGCCAGCATTGTTGACGGATGAGCATATACTTCAGCCATTTGACTGTGGAAATGAGGTGCT
AAGTAACTGGTTACGTGGTCGGGCTATGAAAAACCAGATGCTCAATGCTTCTCGCACGTTCGTTATTTGCTTGGAGGATA
CTTTACGTATTGTGGGATACTACTCATTAGCTACTGGTTCCGTCACTCATGCCGAGCTTGGTCGCAGTTTGCGGCATAAC
ATGCCCAATCCTGTCCCTGTTGTTCTGTTAGGGCGTCTGGCTGTTGATGTTTGTACCCAGGGGCATGGTTTCGGTAAATG
GCTACTAAGTGATGCCATTCACCGGGTTGTCAATCTGGCTGATCAGGTTGGCATTAAGGCTGTTATGGTACATGCAATTG
ATGATAACGCCAGAGCATTTTATGAGCGTTTTGGTTTTGTTCAGTCAGTTGTGGCACCTAATACCTTGTTTTATAAAGTC
TGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT237296 WP_019076175.1 NZ_CP092860:3869057-3869431 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT237296 NZ_LR878366:46428-46730 [Shigella flexneri 3a]
ATGGAGGTTTTTATGTCTACAGCTGCAAGCGTCCGTAAAACACCGCGAGAACATCAGATTAACATCCGGGCAACTGATGA
GGAACGAGCCGTTATTGATTATGCTGCGAGCTTGGTCAATAAGAACCGTACCGATTTCATCATGGAACTGGCGTACCAGG
AAGCTAAAAACATTATCCTGGATCAACGTTTATTTGTGCTGGATAACGAACGTTATGATTCGTTTATTACGCAACTGGAA
GCTCCTGTGCAGAATGCAGAAGGGCGTGAACGTCTGATGGCGGTAAAGCCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References