Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2535909..2536545 Replicon chromosome
Accession NZ_CP092860
Organism Citrobacter braakii strain P1

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag MJ613_RS12555 Protein ID WP_049259794.1
Coordinates 2535909..2536097 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MJ613_RS12560 Protein ID WP_131341011.1
Coordinates 2536129..2536545 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ613_RS12535 (MJ613_12525) 2532687..2532917 - 231 WP_016153158.1 DUF2554 family protein -
MJ613_RS12540 (MJ613_12530) 2533107..2533232 - 126 WP_003020230.1 DUF2474 domain-containing protein -
MJ613_RS12545 (MJ613_12535) 2533232..2534242 - 1011 WP_185654627.1 cytochrome d ubiquinol oxidase subunit II -
MJ613_RS12550 (MJ613_12540) 2534242..2535645 - 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
MJ613_RS12555 (MJ613_12545) 2535909..2536097 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
MJ613_RS12560 (MJ613_12550) 2536129..2536545 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MJ613_RS12565 (MJ613_12555) 2536638..2538047 + 1410 WP_185654626.1 PLP-dependent aminotransferase family protein -
MJ613_RS12570 (MJ613_12560) 2538377..2539522 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
MJ613_RS12575 (MJ613_12565) 2539539..2540555 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
MJ613_RS12580 (MJ613_12570) 2540556..2541500 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T237287 WP_049259794.1 NZ_CP092860:2535909-2536097 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

>T237287 NZ_LR878365:c2278386-2278231 [Shigella flexneri 3a]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT237287 WP_131341011.1 NZ_CP092860:2536129-2536545 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp

>AT237287 NZ_LR878365:2278398-2278456 [Shigella flexneri 3a]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References