237286

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 854347..855001 Replicon chromosome
Accession NZ_CP092860
Organism Citrobacter braakii strain P1

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag MJ613_RS04135 Protein ID WP_016154348.1
Coordinates 854594..855001 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag MJ613_RS04130 Protein ID WP_016154349.1
Coordinates 854347..854613 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ613_RS04105 (MJ613_04100) 849560..850993 - 1434 WP_185654449.1 6-phospho-beta-glucosidase BglA -
MJ613_RS04110 (MJ613_04105) 851114..851842 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
MJ613_RS04115 (MJ613_04110) 851895..852206 + 312 WP_101700204.1 N(4)-acetylcytidine aminohydrolase -
MJ613_RS04120 (MJ613_04115) 852370..853029 + 660 WP_016154351.1 hemolysin III family protein -
MJ613_RS04125 (MJ613_04120) 853109..854089 - 981 WP_019077629.1 tRNA-modifying protein YgfZ -
MJ613_RS04130 (MJ613_04125) 854347..854613 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
MJ613_RS04135 (MJ613_04130) 854594..855001 + 408 WP_016154348.1 protein YgfX Toxin
MJ613_RS04140 (MJ613_04135) 855102..855623 - 522 WP_016154347.1 flavodoxin FldB -
MJ613_RS04145 (MJ613_04140) 855737..856633 + 897 WP_046274931.1 site-specific tyrosine recombinase XerD -
MJ613_RS04150 (MJ613_04145) 856657..857370 + 714 WP_047357820.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MJ613_RS04155 (MJ613_04150) 857376..859109 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T237286 WP_016154348.1 NZ_CP092860:854594-855001 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

>T237286 NZ_LR878365:1949095-1949198 [Shigella flexneri 3a]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTTTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT237286 WP_016154349.1 NZ_CP092860:854347-854613 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237286 NZ_LR878365:c1949199-1948965 [Shigella flexneri 3a]
TAAAAAAAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCA
TTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAAT
AAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCGTTCTGGTGAAAGAACTGAGGCGTTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References