Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pemIK/MazF-doc |
| Location | 15034..15617 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP092858 | ||
| Organism | Staphylococcus capitis strain LR 95 | ||
Toxin (Protein)
| Gene name | pemK | Uniprot ID | A0A507ST80 |
| Locus tag | MMG96_RS12770 | Protein ID | WP_030065368.1 |
| Coordinates | 15034..15372 (-) | Length | 113 a.a. |
Antitoxin (Protein)
| Gene name | pemI | Uniprot ID | C5QR43 |
| Locus tag | MMG96_RS12775 | Protein ID | WP_002442045.1 |
| Coordinates | 15369..15617 (-) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMG96_RS12725 (MMG96_12725) | 10192..10440 | + | 249 | WP_030064697.1 | hypothetical protein | - |
| MMG96_RS12730 (MMG96_12730) | 10437..10775 | + | 339 | WP_030064695.1 | type II toxin-antitoxin system PemK/MazF family toxin | - |
| MMG96_RS12735 (MMG96_12735) | 11425..11910 | + | 486 | WP_002469635.1 | hypothetical protein | - |
| MMG96_RS12740 (MMG96_12740) | 12028..12588 | - | 561 | WP_030064977.1 | TIGR00730 family Rossman fold protein | - |
| MMG96_RS12745 (MMG96_12745) | 12795..12890 | + | 96 | WP_000889979.1 | type I toxin-antitoxin system Fst family toxin | - |
| MMG96_RS12750 (MMG96_12750) | 13087..13353 | + | 267 | Protein_19 | replication initiation protein | - |
| MMG96_RS12755 (MMG96_12755) | 14017..14622 | - | 606 | WP_037582495.1 | stage II sporulation protein M | - |
| MMG96_RS12760 (MMG96_12760) | 14702..14788 | - | 87 | Protein_21 | IS6 family transposase | - |
| MMG96_RS12765 (MMG96_12765) | 14773..14841 | - | 69 | Protein_22 | IS6 family transposase | - |
| MMG96_RS12770 (MMG96_12770) | 15034..15372 | - | 339 | WP_030065368.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
| MMG96_RS12775 (MMG96_12775) | 15369..15617 | - | 249 | WP_002442045.1 | hypothetical protein | Antitoxin |
| MMG96_RS13025 | 15784..15912 | - | 129 | WP_002442043.1 | hypothetical protein | - |
| MMG96_RS12780 (MMG96_12780) | 15966..16247 | - | 282 | WP_227531492.1 | hypothetical protein | - |
| MMG96_RS12785 (MMG96_12785) | 16291..16965 | + | 675 | WP_241065133.1 | IS6 family transposase | - |
| MMG96_RS12790 (MMG96_12790) | 17072..17290 | - | 219 | Protein_28 | plasmid mobilization relaxosome protein MobC | - |
| MMG96_RS12795 (MMG96_12795) | 17715..18236 | - | 522 | WP_141497666.1 | hypothetical protein | - |
| MMG96_RS12800 (MMG96_12800) | 19061..19224 | - | 164 | Protein_30 | RepB family plasmid replication initiator protein | - |
| MMG96_RS12805 (MMG96_12805) | 19281..19955 | + | 675 | WP_096389079.1 | IS6 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaZ | - | 1..31876 | 31876 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 113 a.a. Molecular weight: 13077.20 Da Isoelectric Point: 9.6568
>T237284 WP_030065368.1 NZ_CP092858:c15372-15034 [Staphylococcus capitis]
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWVLPITNREKRYPLDIEVKTKKGLVTGVIDTLQIRALD
LSVREHNYKDELQDNLKNVVLQAIQTYLKPSS
MSIKQFDIYYIDLDPTRGREKQKIRPCLIVNNKMTIDGTNFVWVLPITNREKRYPLDIEVKTKKGLVTGVIDTLQIRALD
LSVREHNYKDELQDNLKNVVLQAIQTYLKPSS
Download Length: 339 bp
>T237284 NZ_LR878365:1017176-1017487 [Shigella flexneri 3a]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAGATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAGGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACGCCAGAAGAGATGCGAACGGCGTTTCCCAACCTCGACAATTTTAAATATC
GCAACAAATGGTACGTTCTGGATGTAGGTGGGAACAACCTAGGGGTGATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACTAATCACGCCGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9210.33 Da Isoelectric Point: 4.5463
>AT237284 WP_002442045.1 NZ_CP092858:c15617-15369 [Staphylococcus capitis]
MIKTSERIFKSGNSKALSLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGKYTEPEFDFGESVGR
EI
MIKTSERIFKSGNSKALSLSKQTIQLADFEVGDKVEVSEINGGLFIKKKEESIEDEITNFFKNGGKYTEPEFDFGESVGR
EI
Download Length: 249 bp
>AT237284 NZ_LR878365:1017484-1017903 [Shigella flexneri 3a]
ATGACTGCTAATGCTGCACACGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
ATGACTGCTAATGCTGCACACGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGTAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAATATGAAAACAACAACCAAGAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCTGTT
GGCGTGGCGTTACTTCGCACGCTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A507ST80 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2J6P0H1 |