Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2120109..2120584 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name TsaT Uniprot ID A0A1J4E6X5
Locus tag MMG96_RS10310 Protein ID WP_002433387.1
Coordinates 2120399..2120584 (+) Length 62 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID A0A1J4E704
Locus tag MMG96_RS10305 Protein ID WP_023350634.1
Coordinates 2120109..2120366 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS10270 (MMG96_10270) 2115363..2116082 - 720 WP_030064992.1 type I 3-dehydroquinate dehydratase -
MMG96_RS10275 (MMG96_10275) 2116252..2116674 + 423 WP_002433175.1 organic hydroperoxide resistance protein -
MMG96_RS10280 (MMG96_10280) 2117083..2117589 + 507 WP_030064990.1 GNAT family N-acetyltransferase -
MMG96_RS10285 (MMG96_10285) 2117770..2118387 + 618 WP_030064988.1 LysE/ArgO family amino acid transporter -
MMG96_RS10290 (MMG96_10290) 2118443..2119027 - 585 WP_030064986.1 histidine phosphatase family protein -
MMG96_RS10295 (MMG96_10295) 2119239..2119475 + 237 WP_002433110.1 hypothetical protein -
MMG96_RS10300 (MMG96_10300) 2119467..2119670 - 204 WP_002432976.1 sterile alpha motif-like domain-containing protein -
MMG96_RS10305 (MMG96_10305) 2120109..2120366 + 258 WP_023350634.1 hypothetical protein Antitoxin
MMG96_RS10310 (MMG96_10310) 2120399..2120584 + 186 WP_002433387.1 hypothetical protein Toxin
MMG96_RS10315 (MMG96_10315) 2120778..2121362 + 585 WP_030064984.1 lipoprotein N-acylation protein LnsA -
MMG96_RS10320 (MMG96_10320) 2121425..2121658 - 234 WP_002433190.1 hypothetical protein -
MMG96_RS10325 (MMG96_10325) 2121792..2122397 - 606 WP_002433231.1 GNAT family N-acetyltransferase -
MMG96_RS10330 (MMG96_10330) 2122578..2123324 + 747 WP_023350637.1 poly-gamma-glutamate hydrolase family protein -
MMG96_RS10335 (MMG96_10335) 2123445..2123729 + 285 WP_030064982.1 hypothetical protein -
MMG96_RS10340 (MMG96_10340) 2123753..2123977 + 225 WP_002433282.1 hypothetical protein -
MMG96_RS10345 (MMG96_10345) 2124287..2125021 - 735 WP_030064980.1 SGNH/GDSL hydrolase family protein -
MMG96_RS10350 (MMG96_10350) 2125144..2125344 - 201 WP_002433447.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(84-135)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7022.71 Da        Isoelectric Point: 9.7844

>T237282 WP_002433387.1 NZ_CP092857:2120399-2120584 [Staphylococcus capitis]
VSLHFQILLWLAIIFIVAGAIILTIMLKTKKEERKESYLGFTVIFLIFGFAMLIYTLIFGL

Download         Length: 186 bp

>T237282 NZ_LR878365:645009-645323 [Shigella flexneri 3a]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAACACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9786.89 Da        Isoelectric Point: 3.6988

>AT237282 WP_023350634.1 NZ_CP092857:2120109-2120366 [Staphylococcus capitis]
MKIFSINVINILLTILFIAFNVLITYNANVDNQLWLIPGLCICGVALFTSLIIAIIYTDLLSEIIFFINIVLALYYIYPI
FYDFL

Download         Length: 258 bp

>AT237282 NZ_LR878365:645320-645736 [Shigella flexneri 3a]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATCGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E6X5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E704

References