Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1122034..1122840 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name tsbT Uniprot ID A0A507SPY8
Locus tag MMG96_RS05610 Protein ID WP_023350045.1
Coordinates 1122661..1122840 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag MMG96_RS05605 Protein ID WP_168992767.1
Coordinates 1122034..1122633 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS05585 (MMG96_05585) 1117922..1119379 + 1458 WP_023350042.1 ABC transporter substrate-binding protein/permease -
MMG96_RS05590 (MMG96_05590) 1119372..1120094 + 723 WP_030063521.1 amino acid ABC transporter ATP-binding protein -
MMG96_RS05595 (MMG96_05595) 1120218..1121381 + 1164 WP_087671673.1 tRNA epoxyqueuosine(34) reductase QueG -
MMG96_RS05600 (MMG96_05600) 1121384..1121854 + 471 WP_023350044.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
MMG96_RS05605 (MMG96_05605) 1122034..1122633 + 600 WP_168992767.1 glucosamine-6-phosphate isomerase Antitoxin
MMG96_RS05610 (MMG96_05610) 1122661..1122840 + 180 WP_023350045.1 SAS053 family protein Toxin
MMG96_RS05615 (MMG96_05615) 1123027..1123425 + 399 WP_023350046.1 hypothetical protein -
MMG96_RS05620 (MMG96_05620) 1123579..1124964 + 1386 WP_023350047.1 class II fumarate hydratase -
MMG96_RS05625 (MMG96_05625) 1125062..1125893 - 832 Protein_1077 RluA family pseudouridine synthase -
MMG96_RS05630 (MMG96_05630) 1126069..1127181 + 1113 WP_030063524.1 GAF domain-containing sensor histidine kinase -
MMG96_RS05635 (MMG96_05635) 1127201..1127824 + 624 WP_023350050.1 response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(125-195)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 7012.37 Da        Isoelectric Point: 3.8420

>T237278 WP_023350045.1 NZ_CP092857:1122661-1122840 [Staphylococcus capitis]
MNKEYESKLNYHEEENAMVTDLDDLKELGKEMEQISEENDEDKLNQSHDEDVHSDLNNE

Download         Length: 180 bp

>T237278 NZ_LR861807:c4751305-4751171 [Xanthomonas arboricola pv. juglandis]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCTGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22734.66 Da        Isoelectric Point: 4.7928

>AT237278 WP_168992767.1 NZ_CP092857:1122034-1122633 [Staphylococcus capitis]
MAMNFKVFENSERVAEYAADIIRKQFNNNPTTIAGFHLEKDHAPVLDELKKNVDTHALDFSQINILDYDDNRSYYEALGV
PESQVYSISYEQDAIDFISDKMKTKENKGKLILQVLSIDESGKLDVSVRQGLMEAREIFLVVTGSNKREVIEKLYRENGK
SSYEPADLKAHRMVNVILDKEAAAGLPEDVKEYFTARYV

Download         Length: 600 bp

>AT237278 NZ_LR861807:c4751540-4751388 [Xanthomonas arboricola pv. juglandis]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCCGGCGC
TGGCAAGGACATGCAGGGTGCAGGTGAGAAGGTCGAAAAGAAGGCCGACAATTGCAGCGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A507SPY8

Antitoxin

Source ID Structure

References