Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-doc
Location 978906..979531 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name doc Uniprot ID Q5HMS9
Locus tag MMG96_RS04715 Protein ID WP_002504557.1
Coordinates 979136..979531 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A4Y7VKS9
Locus tag MMG96_RS04710 Protein ID WP_002504558.1
Coordinates 978906..979136 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS04645 (MMG96_04645) 973975..974457 + 483 WP_030063552.1 hypothetical protein -
MMG96_RS04650 (MMG96_04650) 974473..974652 + 180 WP_002504569.1 hypothetical protein -
MMG96_RS04655 (MMG96_04655) 974637..974822 + 186 WP_001187008.1 hypothetical protein -
MMG96_RS04660 (MMG96_04660) 974838..975122 + 285 WP_002504568.1 hypothetical protein -
MMG96_RS04665 (MMG96_04665) 975119..975274 + 156 WP_002504567.1 transcriptional activator RinB -
MMG96_RS04670 (MMG96_04670) 975300..975572 + 273 WP_002504566.1 hypothetical protein -
MMG96_RS04675 (MMG96_04675) 975588..976130 + 543 WP_002504565.1 hypothetical protein -
MMG96_RS04680 (MMG96_04680) 976123..976299 + 177 WP_002504564.1 hypothetical protein -
MMG96_RS04685 (MMG96_04685) 976319..976540 + 222 WP_002504563.1 hypothetical protein -
MMG96_RS04690 (MMG96_04690) 976540..977265 + 726 WP_010959229.1 metallophosphoesterase -
MMG96_RS04695 (MMG96_04695) 977258..977575 + 318 WP_002504561.1 hypothetical protein -
MMG96_RS04700 (MMG96_04700) 977575..978225 + 651 WP_002504560.1 hypothetical protein -
MMG96_RS04705 (MMG96_04705) 978225..978743 + 519 WP_002504559.1 metallophosphoesterase -
MMG96_RS04710 (MMG96_04710) 978906..979136 + 231 WP_002504558.1 addiction module antitoxin Antitoxin
MMG96_RS04715 (MMG96_04715) 979136..979531 + 396 WP_002504557.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
MMG96_RS04720 (MMG96_04720) 979834..980025 + 192 WP_002504556.1 hypothetical protein -
MMG96_RS04725 (MMG96_04725) 980009..980278 + 270 WP_000755772.1 hypothetical protein -
MMG96_RS04730 (MMG96_04730) 980335..980829 + 495 WP_010959224.1 hypothetical protein -
MMG96_RS04735 (MMG96_04735) 980833..981633 + 801 WP_000686449.1 metallophosphoesterase -
MMG96_RS04740 (MMG96_04740) 981742..982464 + 723 WP_002504538.1 hypothetical protein -
MMG96_RS04745 (MMG96_04745) 982570..983211 + 642 WP_002504537.1 hypothetical protein -
MMG96_RS13005 983242..983376 - 135 WP_002504536.1 hypothetical protein -
MMG96_RS04750 (MMG96_04750) 983459..983863 - 405 WP_002504535.1 YolD-like family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage aac(6')-aph(2'') - 946211..1012219 66008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(3-129)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14992.31 Da        Isoelectric Point: 9.4885

>T237277 WP_002504557.1 NZ_CP092857:979136-979531 [Staphylococcus capitis]
MQSTKYLTEKQVIAINVKAIQDFSPKEQVGVKVPEVLNATIEGVKQSFGGVELYETIERKAAFIYRNIAQKHAFHNANKR
TAFTSMVIFLKLNSINFECTQDEAVQFTLRVVNDKNLTLEGIETWIKRHCK

Download         Length: 396 bp

>T237277 NZ_LR861807:73064-73363 [Xanthomonas arboricola pv. juglandis]
ATGGCTGAAATAGTCTGGTCTGAGCCGGCAGTGGCCGACCTGGACGCGATTGCCGACTACATTGCGCTTGAGGACGCTGC
CGCCGCAGCGGCACTGGTGAGACGGGTGTTTGCGCATGTCGAGCAATTGGCCGAACACCCGGAGAGTGGAAGCCGGCCGC
AGGAGCTCAAGCGCTCCCGCTACCGTCAAATCGTCGAGCCACCTTGCCGCGTGTTCTACCGTGTGGACGGGCAACGCGTT
GTCGTGGTTCACGTGATGCGCTCGGAGCGGTTACTTCGGAAGAATCGTCTTTCGCGCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8648.89 Da        Isoelectric Point: 5.1231

>AT237277 WP_002504558.1 NZ_CP092857:978906-979136 [Staphylococcus capitis]
MITTRKLRKAGNSSVVSVPTEVIAALGISNGDNLKFNVKDNKVTIEKEVREDEEFFKLLDETFTEYNQALKRMVDL

Download         Length: 231 bp

>AT237277 NZ_LR861807:72819-73076 [Xanthomonas arboricola pv. juglandis]
ATGCGCACAGAACTTGTCACCACGCTCAAGCGGCAGGCCACCGAGCTCCTCGCAGATGTCGAGCGCGACAAGGAGCCGAT
CCTGATCACCCAGCATGGCCTGCCCAGCGCATACCTGGTGGACGTCGCCAGCTATGAACGCATGCAACAGCGCATGGCGA
TCCTCGAAGGAATTGCCCGTGGTGAAATGGCGGTAGCCGAAGGCCGCAGCCTGAGCCACGAGCAAGCCAAACAACGCCTG
GCGCGATGGCTGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4Y7VKP2

Antitoxin

Source ID Structure
AlphaFold DB A0A4Y7VKS9

References