Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 841273..841796 Replicon chromosome
Accession NZ_CP092857
Organism Staphylococcus capitis strain LR 95

Toxin (Protein)


Gene name mazF Uniprot ID A0A1J4E8Y2
Locus tag MMG96_RS04015 Protein ID WP_002435799.1
Coordinates 841440..841796 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1J4E747
Locus tag MMG96_RS04010 Protein ID WP_002435513.1
Coordinates 841273..841443 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMG96_RS03985 (MMG96_03985) 837100..837579 + 480 WP_023351370.1 PH domain-containing protein -
MMG96_RS03990 (MMG96_03990) 837572..839071 + 1500 WP_030063298.1 PH domain-containing protein -
MMG96_RS03995 (MMG96_03995) 839064..839564 + 501 WP_023351372.1 PH domain-containing protein -
MMG96_RS04000 (MMG96_04000) 839613..839969 + 357 WP_002435510.1 holo-ACP synthase -
MMG96_RS04005 (MMG96_04005) 840036..841184 + 1149 WP_023351373.1 alanine racemase -
MMG96_RS04010 (MMG96_04010) 841273..841443 + 171 WP_002435513.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
MMG96_RS04015 (MMG96_04015) 841440..841796 + 357 WP_002435799.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MMG96_RS04020 (MMG96_04020) 842175..843176 + 1002 WP_030063302.1 PP2C family protein-serine/threonine phosphatase -
MMG96_RS04025 (MMG96_04025) 843278..843604 + 327 WP_002435753.1 anti-sigma factor antagonist -
MMG96_RS04030 (MMG96_04030) 843606..844085 + 480 WP_002435518.1 anti-sigma B factor RsbW -
MMG96_RS04035 (MMG96_04035) 844060..844830 + 771 WP_002435824.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13327.44 Da        Isoelectric Point: 9.8770

>T237276 WP_002435799.1 NZ_CP092857:841440-841796 [Staphylococcus capitis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSESKMKEVDNALDISLGLHNFDHQ

Download         Length: 357 bp

>T237276 NZ_LR861805:4800792-4801208 [Xanthomonas sp. CPBF 426]
GTGATCCTGCTCGATACCAATGTCATCTCCGAGCTTTGGCGGCCTCAGCCCAACCCGAAGGTCGTTGCCTGGATCGATGC
GCAGGCTGTCGAGACACTGTTCCTGTCGGTGGTAACGGTGGCCGAATTGCGTTTTGGCATTGCCGTGATGCCCGAGGGCC
GCAAGCGATCCACGTTGCATGCACGGTTGGAAAGCGATGTATTGCCACTGTTCAATGGGCGCCTGCTGGCGTTTGATCTG
GACGCATCGCACGCATTCGCGACACTCGCATCGAAAGCCAGAGCCGCAGGACTCACACTCGGTCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGCCTGACCGTTGCCACTCGCGACACGGCACCGTTCGCGGCGATGGCGCTGGACGTCA
TTGACCCGTGGAGTTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6263.87 Da        Isoelectric Point: 4.0121

>AT237276 WP_002435513.1 NZ_CP092857:841273-841443 [Staphylococcus capitis]
MLSFNQSRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNSKNE

Download         Length: 171 bp

>AT237276 NZ_LR861805:4800541-4800795 [Xanthomonas sp. CPBF 426]
ATGCCTTCTTTCACCGTCCGCAATATCCCCGATGAGGTGCATCGCGCGATCCGCGCGAGGGCCGCACTCCACGGCCGCAG
CACCGAGGCGGAGATCCGCGCAATCCTTGAATCAGCGGCCAAACCGGCAGACCGGGTCAAACTCGGCTCCCTGCTGGTGG
ACATTGGCCGCGACGCTGGCCTGACAGCAAAACAGGCCGACGCGTTCGACACCTTACGCGACAAGACCGCAATCAAGCCG
ATCAGCCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J4E8Y2

Antitoxin

Source ID Structure
AlphaFold DB A0A1J4E747

References