Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 1015700..1016295 Replicon chromosome
Accession NZ_CP092853
Organism Burkholderia contaminans strain B17-01563-1

Toxin (Protein)


Gene name chpB Uniprot ID A0A1E3FP25
Locus tag MMB18_RS35680 Protein ID WP_039362634.1
Coordinates 1015700..1016050 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A0G3Z282
Locus tag MMB18_RS35685 Protein ID WP_039362633.1
Coordinates 1016044..1016295 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB18_RS35670 (MMB18_35670) 1012555..1014015 + 1461 WP_039362635.1 efflux RND transporter periplasmic adaptor subunit -
MMB18_RS35675 (MMB18_35675) 1014047..1015576 + 1530 WP_039362750.1 efflux transporter outer membrane subunit -
MMB18_RS35680 (MMB18_35680) 1015700..1016050 - 351 WP_039362634.1 type II toxin-antitoxin system ChpB family toxin Toxin
MMB18_RS35685 (MMB18_35685) 1016044..1016295 - 252 WP_039362633.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MMB18_RS35690 (MMB18_35690) 1016828..1018648 + 1821 WP_046197074.1 asparagine synthase (glutamine-hydrolyzing) -
MMB18_RS35695 (MMB18_35695) 1018880..1020340 - 1461 WP_039362631.1 heavy metal sensor histidine kinase -
MMB18_RS35700 (MMB18_35700) 1020337..1021014 - 678 WP_039362629.1 heavy metal response regulator transcription factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12403.30 Da        Isoelectric Point: 10.0752

>T237272 WP_039362634.1 NZ_CP092853:c1016050-1015700 [Burkholderia contaminans]
MVRRVKFERGDIVRVSLNPTVGKEQQGDFRPALVLSPAAFNALGVALVAPITQGGEFARYAGFAVPLSGSGTETQGVALV
NMVRTLDLQARGARKVERAPSEVIEDALARLQTILE

Download         Length: 351 bp

>T237272 NZ_LR861803:4842085-4842501 [Xanthomonas euroxanthea]
GTGATCCTGCTCGATACCAATGTCATCTCCGAGCTTTGGCGGCCTCAGCCCAACCCGAAGGTCGTTGCCTGGATCGATGC
GCAGGCTGTCGAGACACTGTTCCTGTCGGTGGTAACGGTGGCCGAATTGCGTTTTGGCATTGCAGTGATGCCCGAGGGCC
GCAAGCGATCCACGTTGCATGCACGGTTGGAAAGCGATGTATTGCCGCTGTTCAATGGGCGCCTGCTGGCGTTTGATCTG
GACGCATCGCACGCATTCGCGACACTCGCATCGAAAGCCAGAGCCGCAGGACTCACACTCGGTCGCGCCGATGCCTACAT
CGCTGCAACGGCAGCCGCGCAAGGCCTGACCGTTGCCACCCGCGATACGGCACCGTTCGCGGCGATGGCGCTGGACGTCA
TTGACCCGTGGAGTTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8948.19 Da        Isoelectric Point: 4.7204

>AT237272 WP_039362633.1 NZ_CP092853:c1016295-1016044 [Burkholderia contaminans]
MELKIQKWGNSAAVRLPAVLLEQIDASVGSSLNADVRPDGVLLSPARRKYSLDELIAQCDPKAPEPADLAAWGESKPVGH
EAW

Download         Length: 252 bp

>AT237272 NZ_LR861803:4841834-4842088 [Xanthomonas euroxanthea]
ATGCCTTCTTTCACCGTCCGCAATATCCCCGATGAGGTGCATCGCGCGATCCGCGCGAGGGCCGCACTCCACGGCCGCAG
CACCGAGGCGGAGATCCGCGCAATCCTTGAATCAGCGGCCAAACCGGCAGACCGGGTCAAACTCGGCTCCCTGCTGGTGG
ACATTGGCCGCGACGCTGGCCTGACCGCAAAACAGGCCGACGCGTTCGACACCTTACGCGACAAGACCGCAATCAAGCCG
ATCAGCCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E3FP25

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3Z282

References