Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1338435..1339055 Replicon chromosome
Accession NZ_CP092852
Organism Burkholderia contaminans strain B17-01563-1

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MMB18_RS22615 Protein ID WP_095146199.1
Coordinates 1338435..1338752 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1J9PWC2
Locus tag MMB18_RS22620 Protein ID WP_039344756.1
Coordinates 1338756..1339055 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB18_RS22605 (MMB18_22605) 1334979..1336412 - 1434 WP_039344747.1 aldehyde dehydrogenase family protein -
MMB18_RS22610 (MMB18_22610) 1336442..1338082 - 1641 WP_039344750.1 acetolactate synthase large subunit -
MMB18_RS22615 (MMB18_22615) 1338435..1338752 + 318 WP_095146199.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MMB18_RS22620 (MMB18_22620) 1338756..1339055 + 300 WP_039344756.1 putative addiction module antidote protein Antitoxin
MMB18_RS22625 (MMB18_22625) 1339104..1340390 - 1287 WP_039344759.1 DUF445 domain-containing protein -
MMB18_RS22630 (MMB18_22630) 1340561..1341781 - 1221 WP_039344761.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
MMB18_RS22635 (MMB18_22635) 1341771..1342097 - 327 WP_039344765.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
MMB18_RS22640 (MMB18_22640) 1342118..1342606 - 489 WP_011355917.1 anthranilate 1,2-dioxygenase small subunit AndAd -
MMB18_RS22645 (MMB18_22645) 1342621..1343892 - 1272 WP_039344770.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-91)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11796.53 Da        Isoelectric Point: 9.9432

>T237270 WP_095146199.1 NZ_CP092852:1338435-1338752 [Burkholderia contaminans]
MPYSAPTFSIRTTGVFDTWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSSQQADIRAAHAMLAHLDME

Download         Length: 318 bp

>T237270 NZ_LR861803:c4487751-4487617 [Xanthomonas euroxanthea]
ATGAAGCGTGCAATTGTGCTGCTGGTGCTGTCGGTGTTGTCGGTCGGTATGCTGTCGGGTTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGCAGGGCGCCGGCGAGAAGGTGGAAGACGCTGCGCGCAAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10649.01 Da        Isoelectric Point: 6.3217

>AT237270 WP_039344756.1 NZ_CP092852:1338756-1339055 [Burkholderia contaminans]
MDKISTRPWDSADHLKTEDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGSKAHA

Download         Length: 300 bp

>AT237270 NZ_LR861803:c4487982-4487830 [Xanthomonas euroxanthea]
ATGAAGCGACTGCTGACACTGATGGTACTGGGCCTGTTTTCGGCCGGCGTGATGACTGGCTGCAACACCATGGCTGGCGC
CGGCAAGGACATGCAGGGCGCGGGCGAGAAGGTCGAGAAGAAGGCCGACAATTGCAGTGACGGTAAGTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9PWC2

References