Detailed information of TA system TA237268

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 470671..471310
• Replicon: chromosome
• Accession: NZ_CP092852
• Organism: Burkholderia contaminans strain B17-01563-1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: MMB18_RS18800
• Protein ID: WP_223274309.1
• Coordinates: 470894..471310 (+)
• Length: 139 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1X1PQC0
• Locus tag: MMB18_RS18795
• Protein ID: WP_039351245.1
• Coordinates: 470671..470907 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMB18_RS18780 (MMB18_18780)	466453..468033	+	1581	WP_039350882.1	FadD3 family acyl-CoA ligase	-
MMB18_RS18785 (MMB18_18785)	468072..468845	+	774	WP_039351252.1	SDR family oxidoreductase	-
MMB18_RS18790 (MMB18_18790)	469638..470297	+	660	WP_046196544.1	hypothetical protein	-
MMB18_RS18795 (MMB18_18795)	470671..470907	+	237	WP_039351245.1	DNA-binding protein	Antitoxin
MMB18_RS18800 (MMB18_18800)	470894..471310	+	417	WP_223274309.1	type II toxin-antitoxin system VapC family toxin	Toxin
MMB18_RS18805 (MMB18_18805)	471510..472406	+	897	WP_039350875.1	VOC family protein	-
MMB18_RS18810 (MMB18_18810)	472416..473309	+	894	WP_039350872.1	CoA-transferase	-
MMB18_RS18815 (MMB18_18815)	473320..474117	+	798	WP_039350869.1	ketoacid CoA transferase	-
MMB18_RS18820 (MMB18_18820)	474126..475058	+	933	WP_039350867.1	enoyl-CoA hydratase	-
MMB18_RS18825 (MMB18_18825)	475055..476143	+	1089	WP_039350864.1	nitronate monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-130)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 139 a.a.
• Molecular weight: 15370.68 Da
• Isoelectric Point: 7.4021

>T237268 WP_223274309.1 NZ_CP092852:470894-471310 [Burkholderia contaminans]
VYLIDTNIISEIRKGKRTNRGVRAFFRQAAADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYAPNI
LPVDIEISQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVEDFARTGVKLLNPFD

Nucleotide

• Length: 417 bp

>T237268 NZ_LR828257:c3636836-3636630 [Xanthomonas hortorum pv. vitians]
ATGCAAGCTGTAGCCGAACGGAAGCTGCAATTGCTGGATTCGGCGCAGACGCTGGAGTTCTTGCGCAGCCCGCCGGGCAA
TCGGTTTGAGCTTCTTGCGGGTACGCGTGCAGGTCAGCACAGCATCCGCATCAATGACCAATGGCGTGTGTGCTTTGTCT
GGACTGACGCCGGCCCCGAGCACGTTGAGATTGTCGATTACCACTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8598.61 Da
• Isoelectric Point: 5.0477

>AT237268 WP_039351245.1 NZ_CP092852:470671-470907 [Burkholderia contaminans]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILADALGRPKRKTFAQVLMSMPDVGDDADFQRVQDSGEARRVFD

Nucleotide

• Length: 237 bp

>AT237268 NZ_LR828257:c3636620-3636321 [Xanthomonas hortorum pv. vitians]
ATGCGACCCAACAACAAACTGCGCGCCATCCATCCCGGCGAAATCCTGCGGGAAGATTTCATGCTGCCGCTGGGGCTGAC
CATTAACGGCCTGGCGCGGGCGCTGGATGTACCGGCAACGCGCATCCACAGCATCGTGCATGGCGAGCGTGCCATCAGCG
CCGATACCGCAGCGCGGCTTGCACGCCACTTCGGTGGCGATGCGGCGTCCTGGCTCGCGCTGCAGGCCACGTATGAACTC
AAGACCTTGCCCAACCGCAGCGAGATCGAGCGCAACGTGCAGCCGCGTGTGGCGGCCTAG

Structures

Antitoxin

• AlphaFold DB: A0A1X1PQC0