Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 194938..196688 | Replicon | chromosome |
| Accession | NZ_CP092852 | ||
| Organism | Burkholderia contaminans strain B17-01563-1 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1E3FSX8 |
| Locus tag | MMB18_RS17645 | Protein ID | WP_039344096.1 |
| Coordinates | 194938..195834 (+) | Length | 299 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1E3FSY5 |
| Locus tag | MMB18_RS17650 | Protein ID | WP_039344097.1 |
| Coordinates | 195831..196688 (+) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MMB18_RS17615 (MMB18_17615) | 190308..191387 | - | 1080 | WP_039344086.1 | porin | - |
| MMB18_RS17620 (MMB18_17620) | 191832..192149 | + | 318 | WP_011354710.1 | non-heme iron oxygenase ferredoxin subunit | - |
| MMB18_RS17625 (MMB18_17625) | 192151..192462 | + | 312 | WP_039344088.1 | hypothetical protein | - |
| MMB18_RS17630 (MMB18_17630) | 192515..193591 | + | 1077 | WP_039344090.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| MMB18_RS17635 (MMB18_17635) | 193584..194354 | + | 771 | WP_039344092.1 | SDR family oxidoreductase | - |
| MMB18_RS17640 (MMB18_17640) | 194392..194919 | + | 528 | WP_039344094.1 | cupin domain-containing protein | - |
| MMB18_RS17645 (MMB18_17645) | 194938..195834 | + | 897 | WP_039344096.1 | alpha/beta fold hydrolase | Toxin |
| MMB18_RS17650 (MMB18_17650) | 195831..196688 | + | 858 | WP_039344097.1 | IclR family transcriptional regulator | Antitoxin |
| MMB18_RS17655 (MMB18_17655) | 196685..197482 | + | 798 | WP_039344099.1 | SDR family oxidoreductase | - |
| MMB18_RS17660 (MMB18_17660) | 197475..199142 | + | 1668 | WP_039344101.1 | thiamine pyrophosphate-binding protein | - |
| MMB18_RS17665 (MMB18_17665) | 199135..199962 | + | 828 | WP_039344103.1 | aspartate dehydrogenase | - |
| MMB18_RS17670 (MMB18_17670) | 200035..201525 | + | 1491 | WP_039344105.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 299 a.a. Molecular weight: 30700.99 Da Isoelectric Point: 8.0624
>T237267 WP_039344096.1 NZ_CP092852:194938-195834 [Burkholderia contaminans]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAHHAGRALPVVLLHGIGSGAASWVRQLDTLGASRRVLAW
DAPGYGVSTPVHGASPAATDYAASLNAWLEALGIERCVLVGHSLGAIIAGGLIRVMPARIAGLLLVSPAGGYGSAPAETR
DARRDARLAMLAELGPAGLAEQRSGNMLSGFANEDARAWVRWNMARIVPAGYAQATQLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDAFCRQCDQQRGLA
Download Length: 897 bp
>T237267 NZ_LR828257:c2197926-2197675 [Xanthomonas hortorum pv. vitians]
ATGGACACCATCACCTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCACGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTGGTCATGGTGTCGCTGGAAGATTACAAGGCCATGGAAGAGACCGCCTACC
TGTTGCGCAGCCCGAAGAGTGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA
ATGGACACCATCACCTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCACGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTGGTCATGGTGTCGCTGGAAGATTACAAGGCCATGGAAGAGACCGCCTACC
TGTTGCGCAGCCCGAAGAGTGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31463.03 Da Isoelectric Point: 6.7661
>AT237267 WP_039344097.1 NZ_CP092852:195831-196688 [Burkholderia contaminans]
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MNEPLQRPELENGKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQAPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGTLNRMTNATPETVDALYEVIREDALRGYGVSNSSFERGISVVTAPVRNETQRIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT237267 NZ_LR828257:c2197678-2197421 [Xanthomonas hortorum pv. vitians]
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATCGTTTACAAGGCCGAGAACGGCATCCTGTTGATTGCTCAGGCG
CGCTACCACTACGGGTAA
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATCGTTTACAAGGCCGAGAACGGCATCCTGTTGATTGCTCAGGCG
CGCTACCACTACGGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E3FSX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1E3FSY5 |