Detailed information of TA system TA237266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1853909..1854439
• Replicon: chromosome
• Accession: NZ_CP092851
• Organism: Burkholderia contaminans strain B17-01563-1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: MMB18_RS08455
• Protein ID: WP_232490759.1
• Coordinates: 1854200..1854439 (+)
• Length: 80 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: MMB18_RS08450
• Protein ID: WP_076841742.1
• Coordinates: 1853909..1854154 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMB18_RS08415 (MMB18_08415)	1848974..1849990	+	1017	WP_039358635.1	GNAT family N-acetyltransferase	-
MMB18_RS08420 (MMB18_08420)	1850240..1850506	+	267	WP_046196769.1	type II toxin-antitoxin system VapB family antitoxin	-
MMB18_RS08425 (MMB18_08425)	1850503..1850664	+	162	WP_223274361.1	type II toxin-antitoxin system VapC family toxin	-
MMB18_RS08430 (MMB18_08430)	1850692..1850919	+	228	WP_223274360.1	hypothetical protein	-
MMB18_RS08435 (MMB18_08435)	1850968..1851207	-	240	Protein_1643	nucleotidyltransferase	-
MMB18_RS08440 (MMB18_08440)	1851221..1852309	-	1089	WP_249215684.1	type IV toxin-antitoxin system AbiEi family antitoxin	-
MMB18_RS08445 (MMB18_08445)	1852629..1853792	+	1164	WP_039358627.1	M20 aminoacylase family protein	-
MMB18_RS08450 (MMB18_08450)	1853909..1854154	+	246	WP_076841742.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
MMB18_RS08455 (MMB18_08455)	1854200..1854439	+	240	WP_232490759.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMB18_RS08460 (MMB18_08460)	1854510..1855814	-	1305	WP_039358619.1	cobyrinate a,c-diamide synthase	-
MMB18_RS08465 (MMB18_08465)	1855817..1856419	-	603	WP_039358616.1	cob(I)yrinic acid a,c-diamide adenosyltransferase	-
MMB18_RS08470 (MMB18_08470)	1856457..1856834	-	378	WP_039358613.1	cobalamin biosynthesis protein	-
MMB18_RS08475 (MMB18_08475)	1856831..1857580	-	750	WP_039358610.1	uroporphyrinogen-III C-methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (1-74)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 80 a.a.
• Molecular weight: 9325.66 Da
• Isoelectric Point: 8.0671

>T237266 WP_232490759.1 NZ_CP092851:1854200-1854439 [Burkholderia contaminans]
IWRDTVGRGSLKQTDLYHRDLIGTMEALARGEKVGRTCIVRDGYFRYAVGSHVVFYRETEYTIDLIRVLHQRMDIEQHL

Nucleotide

• Length: 240 bp

>T237266 NZ_LR828257:c2197678-2197421 [Xanthomonas hortorum pv. vitians]
GTGATTCTGCAGTTTGCTGACAATGCCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATCGTTTACAAGGCCGAGAACGGCATCCTGTTGATTGCTCAGGCG
CGCTACCACTACGGGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9021.01 Da
• Isoelectric Point: 5.6864

>AT237266 WP_076841742.1 NZ_CP092851:1853909-1854154 [Burkholderia contaminans]
MSQNASVSRRDHFAELVDTQVQSEQYGSASDVERTGLRLLESRDMQVRALQEALKAGEVSGALRPFDREAFLARMRAAHD
G

Nucleotide

• Length: 246 bp

>AT237266 NZ_LR828257:c2197926-2197675 [Xanthomonas hortorum pv. vitians]
ATGGACACCATCACCTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCACGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTGGTCATGGTGTCGCTGGAAGATTACAAGGCCATGGAAGAGACCGCCTACC
TGTTGCGCAGCCCGAAGAGTGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA