Detailed information of TA system TA237263

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-Xre
• Location: 4615033..4615909
• Replicon: chromosome
• Accession: NZ_CP092848
• Organism: Methylobacterium organophilum strain WPA_B

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMB17_RS21780
• Protein ID: WP_241100246.1
• Coordinates: 4615397..4615909 (+)
• Length: 171 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MMB17_RS21775
• Protein ID: WP_238310905.1
• Coordinates: 4615033..4615404 (+)
• Length: 124 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMB17_RS21745 (MMB17_21745)	4611428..4611700	-	273	WP_238310615.1	cell division topological specificity factor MinE	-
MMB17_RS21750 (MMB17_21750)	4611697..4612512	-	816	WP_238310614.1	septum site-determining protein MinD	-
MMB17_RS21755 (MMB17_21755)	4612525..4613205	-	681	WP_241100245.1	septum site-determining protein MinC	-
MMB17_RS21760 (MMB17_21760)	4613614..4613814	+	201	WP_238310612.1	hypothetical protein	-
MMB17_RS21765 (MMB17_21765)	4613811..4614005	+	195	WP_238310611.1	hypothetical protein	-
MMB17_RS21770 (MMB17_21770)	4614036..4614713	-	678	WP_241102263.1	septum site-determining protein MinC	-
MMB17_RS21775 (MMB17_21775)	4615033..4615404	+	372	WP_238310905.1	DUF2384 domain-containing protein	Antitoxin
MMB17_RS21780 (MMB17_21780)	4615397..4615909	+	513	WP_241100246.1	RES domain-containing protein	Toxin
MMB17_RS21785 (MMB17_21785)	4616102..4617928	+	1827	WP_241100247.1	translational GTPase TypA	-
MMB17_RS21790 (MMB17_21790)	4618002..4618373	-	372	WP_241100248.1	hypothetical protein	-
MMB17_RS21795 (MMB17_21795)	4618419..4618814	-	396	WP_241100249.1	hypothetical protein	-
MMB17_RS21800 (MMB17_21800)	4618811..4619104	-	294	WP_241100250.1	hypothetical protein	-
MMB17_RS21805 (MMB17_21805)	4619295..4619867	+	573	WP_241100251.1	fasciclin domain-containing protein	-
MMB17_RS21810 (MMB17_21810)	4619947..4620642	-	696	WP_241100252.1	anti-sigma factor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (10-163)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (71-120)

Sequences

Toxin

Protein

• Length: 171 a.a.
• Molecular weight: 18782.33 Da
• Isoelectric Point: 8.1243

>T237263 WP_241100246.1 NZ_CP092848:4615397-4615909 [Methylobacterium organophilum]
MPEPGSRLVLWRAYVPRWAHDPLSGAGAARFGGRWNRIGQPCLYAARELSTAWAEYNQGFVQHPATIAQLILKGARLADL
TAPDGLRGLGLPDDLHRAEWRADLDAGRLPETHRAAERLLEAGFHGLIHPSFMSRGGTGIALWRWNGEEGPRLSVIDPEG
RLPKTDAPWL

Nucleotide

• Length: 513 bp

>T237263 NZ_LR828257:914479-914760 [Xanthomonas hortorum pv. vitians]
ATGATAAGGAGCTTTGTCGACAAGGAAGCCGAAAAGATCTGGTTGGGTGAGCGCTCCCGCCGGTTGCCGGCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGTATTCCACCTGCCAACCGGC
TGGAAGCGTTGAAGGGCCAGCGACGCGGGCAGTACAGCATCCGGATCAACGACCAGTGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGACATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 124 a.a.
• Molecular weight: 13281.43 Da
• Isoelectric Point: 9.8945

>AT237263 WP_238310905.1 NZ_CP092848:4615033-4615404 [Methylobacterium organophilum]
MPMSALPSVATLFREADAPYLSPRRVAEGLGLTLTELARLAGISRNTLTASRGTRSVEGALSPIVRIIAMAAEMTGDEMR
AAIWFKHQPIPGWAGKTAYDLVREHKADKVIAYLEAVRAGVYA

Nucleotide

• Length: 372 bp

>AT237263 NZ_LR828257:914778-915068 [Xanthomonas hortorum pv. vitians]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATCCTGCTTGAGGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGCCGTGCCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGCGGCATCACCGCCGACACCG
CCGTGCGCCTGGCCGCCGCGCTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGACTACGAGCTGGAAGAAGCG
CACCGCGCGCTGGGCGACCTGCCGTCACGGATCAAGCGGCTGGCGGCTTGA