Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4411181..4411860 Replicon chromosome
Accession NZ_CP092848
Organism Methylobacterium organophilum strain WPA_B

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MMB17_RS20885 Protein ID WP_241100143.1
Coordinates 4411435..4411860 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MMB17_RS20880 Protein ID WP_238310760.1
Coordinates 4411181..4411438 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMB17_RS20855 (MMB17_20855) 4406551..4408365 + 1815 WP_238310765.1 aspartate--tRNA ligase -
MMB17_RS20860 (MMB17_20860) 4408535..4409410 + 876 WP_238310764.1 glycosyltransferase family 2 protein -
MMB17_RS20865 (MMB17_20865) 4409400..4410473 + 1074 WP_241100141.1 acyltransferase -
MMB17_RS20870 (MMB17_20870) 4410484..4410816 + 333 WP_241100142.1 hypothetical protein -
MMB17_RS20875 (MMB17_20875) 4410786..4411037 - 252 WP_238310761.1 DUF3297 family protein -
MMB17_RS20880 (MMB17_20880) 4411181..4411438 + 258 WP_238310760.1 Arc family DNA-binding protein Antitoxin
MMB17_RS20885 (MMB17_20885) 4411435..4411860 + 426 WP_241100143.1 type II toxin-antitoxin system VapC family toxin Toxin
MMB17_RS20890 (MMB17_20890) 4411899..4412504 - 606 WP_241100144.1 CatB-related O-acetyltransferase -
MMB17_RS20895 (MMB17_20895) 4412583..4414916 + 2334 WP_241100145.1 NADP-dependent malic enzyme -
MMB17_RS20900 (MMB17_20900) 4415072..4415818 + 747 WP_241100146.1 RDD family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15301.64 Da        Isoelectric Point: 8.5486

>T237262 WP_241100143.1 NZ_CP092848:4411435-4411860 [Methylobacterium organophilum]
MIVLDTNVISELWRVVPDPAVRAWIDAQVVETLYLSAVTVAELRLGIAVMSAGKRQRTYRDRLEREVLPAFAGRVLPFDL
DAARHYADFMAQAKTAGRAIAQADGHIAAIAAARGFIVASRDTSPFEAAGVRVVDPWKAAA

Download         Length: 426 bp

>T237262 NZ_LR828253:c5084737-5084456 [Xanthomonas hortorum pv. gardneri]
GTGATCAGGAGCTTTATCGACAAGGAGGCCGAAAAGATCTGGCTGGGTGAGCGCTCCCGCCGGTTGCCGTCCGACATCCA
GTCGGTCGCGCGCCGCAAGTTGCGCATGCTCAACGCTGCCGCGCACCTCGACGATCTGCGCATTCCGCCCGCCAACCGGC
TGGAAGCGTTGAAGGGCGAGCGGCGCGGGCAGTACAGCATCCGGATCAACGACCAATGGCGCATCTGCTTCCGATGGATG
GAGGGCGATGTCGCCGAGGTCGAAATCGTCGATTACCACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9699.98 Da        Isoelectric Point: 7.2082

>AT237262 WP_238310760.1 NZ_CP092848:4411181-4411438 [Methylobacterium organophilum]
MRSVTIRNIPEDVHRALRVRAARHGRSTEAEIRDILEQAAKPEGRLKLGSLLTSIAREAGPLSEEEAENFDQLRDRKPVE
PLRFE

Download         Length: 258 bp

>AT237262 NZ_LR828253:c5084438-5084148 [Xanthomonas hortorum pv. gardneri]
ATGACAGTCCTACCCAACATCCACCCCGGCGAAATTCTGCTCGAAGAGTTTCTCGAGCCGATGGGCATCAGCCAGAACGC
ACTGGCGCGGGCCACCGATGTACCGCCGCGCCGCATCAACGAGATCGTGCTGGGCAAGCGCGGCATCACTGCCGACACCG
CCGTACGCCTGGCTGCCGCGTTGGGCACGACCGAGCGCTTCTGGTTGGGCCTGCAGGCCGATTACGAGCTGGAACAAGCG
CATCGCGCGCTGGGCGATCTGCCGTCACGGATCAAGCGGTTGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References