Detailed information of TA system TA237259

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1623174..1623795
• Replicon: chromosome
• Accession: NZ_CP092848
• Organism: Methylobacterium organophilum strain WPA_B

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MMB17_RS07585
• Protein ID: WP_241101653.1
• Coordinates: 1623174..1623329 (+)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MMB17_RS07590
• Protein ID: WP_241101654.1
• Coordinates: 1623391..1623795 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMB17_RS07555 (MMB17_07555)	1618537..1618989	+	453	WP_241101648.1	hypothetical protein	-
MMB17_RS07560 (MMB17_07560)	1618989..1620962	+	1974	WP_241101649.1	hypothetical protein	-
MMB17_RS07565 (MMB17_07565)	1621171..1621842	+	672	WP_241101650.1	lysozyme	-
MMB17_RS07570 (MMB17_07570)	1621844..1622104	+	261	WP_241101651.1	hypothetical protein	-
MMB17_RS07575 (MMB17_07575)	1622104..1622511	+	408	WP_238310163.1	hypothetical protein	-
MMB17_RS07580 (MMB17_07580)	1622584..1622997	+	414	WP_241101652.1	hypothetical protein	-
MMB17_RS07585 (MMB17_07585)	1623174..1623329	+	156	WP_241101653.1	type II toxin-antitoxin system HicA family toxin	Toxin
MMB17_RS07590 (MMB17_07590)	1623391..1623795	+	405	WP_241101654.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MMB17_RS07595 (MMB17_07595)	1624317..1628261	+	3945	WP_241101655.1	S8 family serine peptidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1592480..1623795	31315

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (2-51)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (4-126)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5496.49 Da
• Isoelectric Point: 11.3441

>T237259 WP_241101653.1 NZ_CP092848:1623174-1623329 [Methylobacterium organophilum]
MLKAAGWTQHSVTGSHHHFKHPAKPGKITVPHPKKDMHPKAVASIKKAAGI

Nucleotide

• Length: 156 bp

>T237259 NZ_LR828253:3811461-3811718 [Xanthomonas hortorum pv. gardneri]
GTGATTCTGCAGTTTGCTGACAATACCTGGGAGGACTACCTCTACTGGCAACAGACCGACAAGAAGATGCTCAAACGCAT
CAACGAGTTGATCAAGGCCATTCAGCGCGATCCTTTCCAGGGCATCGGCAAACCCGAACCGTTGCGCCATGCGCTGGCGG
GCTACTGGTCACGCCGCATCAACGACGAACACCGGATTGTCTACAAGGCCGAGAACGGCATCCTGCTGATTGCTCAGGCG
CGCTACCACTACGCGTAA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14236.94 Da
• Isoelectric Point: 4.3501

>AT237259 WP_241101654.1 NZ_CP092848:1623391-1623795 [Methylobacterium organophilum]
MNSYFAFLHPPEGNSSWGVTFPDLPGCVSEGDTFEEAVHAAREALSGHLAALRADGDPIPAPRTWSEISEDPEVMSTGAL
AQLIAPRRVPGERLRINITIDKGLLRVADEAAEAAGLTRSGFIEKALEAATEPA

Nucleotide

• Length: 405 bp

>AT237259 NZ_LR828253:3811213-3811464 [Xanthomonas hortorum pv. gardneri]
ATGGACACCATCACCTACAGCGCCGCGCGTGCCTCTCTGGCCGACACCATGGACCGTGTCGTCAATGACCACGAGCCGGT
GATCATCACGCGCAGCGGTGAGCGCGCCGTGGTCATGGTGTCGCTGGAAGATTACAAGGCCATGGAAGAGACCGCCTACC
TGTTGCGCAGCCCGAAGAGTGCGCAACGGCTGCTGGAATCCATTGCCCAGCTTGAGGCCGGTCGCGGCAAGGAACGGGAA
CTGGCTGAGTGA