Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2115321..2115941 Replicon chromosome
Accession NZ_CP092844
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MK974_RS25505 Protein ID WP_269017469.1
Coordinates 2115321..2115638 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag MK974_RS25510 Protein ID WP_006750245.1
Coordinates 2115642..2115941 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS25495 (MK974_25465) 2111895..2113328 - 1434 WP_175677245.1 aldehyde dehydrogenase family protein -
MK974_RS25500 (MK974_25470) 2113357..2114997 - 1641 WP_175729498.1 acetolactate synthase large subunit -
MK974_RS25505 (MK974_25475) 2115321..2115638 + 318 WP_269017469.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MK974_RS25510 (MK974_25480) 2115642..2115941 + 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
MK974_RS25515 (MK974_25485) 2115993..2117279 - 1287 WP_165752680.1 DUF445 domain-containing protein -
MK974_RS25520 (MK974_25490) 2117461..2118681 - 1221 WP_269017470.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
MK974_RS25525 (MK974_25495) 2118671..2118997 - 327 WP_006756593.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
MK974_RS25530 (MK974_25500) 2119015..2119503 - 489 WP_006750249.1 anthranilate 1,2-dioxygenase small subunit AndAd -
MK974_RS25535 (MK974_25505) 2119500..2120789 - 1290 WP_126226708.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-94)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11853.61 Da        Isoelectric Point: 9.9422

>T237257 WP_269017469.1 NZ_CP092844:2115321-2115638 [Burkholderia ambifaria]
MPYSAPTFSIRTTDIFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLARLDLE

Download         Length: 318 bp

>T237257 NZ_LR822061:2890911-2891273 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT237257 WP_006750245.1 NZ_CP092844:2115642-2115941 [Burkholderia ambifaria]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT237257 NZ_LR822061:2890744-2890914 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References