Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 964892..965547 Replicon chromosome
Accession NZ_CP092844
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MK974_RS20235 Protein ID WP_175663522.1
Coordinates 965128..965547 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MK974_RS20230 Protein ID WP_041491669.1
Coordinates 964892..965131 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS20215 (MK974_20195) 960888..961571 - 684 WP_269018220.1 Fe2+-dependent dioxygenase -
MK974_RS20220 (MK974_20200) 961568..962323 - 756 WP_269018221.1 tetratricopeptide repeat protein -
MK974_RS20225 (MK974_20205) 962327..964570 - 2244 WP_269018222.1 TonB-dependent siderophore receptor -
MK974_RS20230 (MK974_20210) 964892..965131 + 240 WP_041491669.1 Arc family DNA-binding protein Antitoxin
MK974_RS20235 (MK974_20215) 965128..965547 + 420 WP_175663522.1 type II toxin-antitoxin system VapC family toxin Toxin
MK974_RS20240 (MK974_20220) 965689..966984 - 1296 WP_011659178.1 aspartate carbamoyltransferase -
MK974_RS20245 (MK974_20225) 967220..967354 + 135 WP_011659177.1 entericidin A/B family lipoprotein -
MK974_RS20250 (MK974_20230) 967453..968025 - 573 WP_269018223.1 permease -
MK974_RS20255 (MK974_20235) 968151..969110 - 960 WP_175678606.1 DMT family transporter -
MK974_RS20260 (MK974_20240) 969402..970196 - 795 WP_175733487.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 959344..960624 1280


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-44)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15028.30 Da        Isoelectric Point: 7.0176

>T237250 WP_175663522.1 NZ_CP092844:965128-965547 [Burkholderia ambifaria]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGKRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLRAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAR

Download         Length: 420 bp

>T237250 NZ_LR822061:1279888-1280076 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8618.76 Da        Isoelectric Point: 6.4688

>AT237250 WP_041491669.1 NZ_CP092844:964892-965131 [Burkholderia ambifaria]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPTGRAKLGSLLAEIGREAGGVDFENPRESSPTAPMSFE

Download         Length: 240 bp

>AT237250 NZ_LR822061:1279599-1279859 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References