Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 714029..715276 Replicon chromosome
Accession NZ_CP092844
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MK974_RS19110 Protein ID WP_269018118.1
Coordinates 714029..714610 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MK974_RS19115 Protein ID WP_269018119.1
Coordinates 714719..715276 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS19090 (MK974_19075) 709390..710529 + 1140 WP_269018115.1 enoyl-CoA hydratase/isomerase family protein -
MK974_RS19095 (MK974_19080) 710591..711496 - 906 WP_175676400.1 LysR family transcriptional regulator -
MK974_RS19100 (MK974_19085) 711674..713212 + 1539 WP_269018116.1 MFS transporter -
MK974_RS19105 (MK974_19090) 713242..713970 - 729 WP_269018117.1 class I SAM-dependent methyltransferase -
MK974_RS19110 (MK974_19095) 714029..714610 - 582 WP_269018118.1 HD domain-containing protein Toxin
MK974_RS19115 (MK974_19100) 714719..715276 - 558 WP_269018119.1 helix-turn-helix transcriptional regulator Antitoxin
MK974_RS19120 (MK974_19105) 715348..715995 - 648 WP_269018120.1 hypothetical protein -
MK974_RS19125 (MK974_19110) 716359..717762 + 1404 WP_269018121.1 DUF308 domain-containing protein -
MK974_RS19130 (MK974_19115) 717944..718675 + 732 WP_269018122.1 ribonuclease T2 -
MK974_RS19135 (MK974_19120) 718756..719391 - 636 WP_212116692.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-169)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21455.98 Da        Isoelectric Point: 4.8564

>T237249 WP_269018118.1 NZ_CP092844:c714610-714029 [Burkholderia ambifaria]
MNLDTIHARLDFLREAERLKDVLRSGHTSTGRRESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRTLRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFGAIRAIVDADTQRRIDARGDGA

Download         Length: 582 bp

>T237249 NZ_LR822061:c1004793-1004557 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAATAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20280.21 Da        Isoelectric Point: 11.0874

>AT237249 WP_269018119.1 NZ_CP092844:c715276-714719 [Burkholderia ambifaria]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDHTHRLLACSPSRAAEFSRPLPTLLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGANASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT237249 NZ_LR822061:c1004552-1004370 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References