Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 189492..190129 Replicon chromosome
Accession NZ_CP092843
Organism Burkholderia ambifaria strain Q53

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MK974_RS00785 Protein ID WP_126226938.1
Coordinates 189728..190129 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag MK974_RS00780 Protein ID WP_126228768.1
Coordinates 189492..189728 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK974_RS00760 (MK974_00760) 185477..186580 - 1104 WP_269016373.1 ADP-heptose--LPS heptosyltransferase -
MK974_RS00765 (MK974_00765) 186577..188280 - 1704 WP_269016374.1 thiamine pyrophosphate-binding protein -
MK974_RS00770 (MK974_00770) 188576..189037 + 462 WP_269016375.1 hypothetical protein -
MK974_RS00775 (MK974_00775) 189034..189318 + 285 WP_269016376.1 type II toxin-antitoxin system RelE/ParE family toxin -
MK974_RS00780 (MK974_00780) 189492..189728 + 237 WP_126228768.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MK974_RS00785 (MK974_00785) 189728..190129 + 402 WP_126226938.1 type II toxin-antitoxin system VapC family toxin Toxin
MK974_RS00790 (MK974_00790) 190197..191585 - 1389 WP_011655650.1 L-serine ammonia-lyase -
MK974_RS00795 (MK974_00795) 191616..192752 - 1137 WP_175665527.1 alginate lyase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-120)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15032.19 Da        Isoelectric Point: 5.1782

>T237247 WP_126226938.1 NZ_CP092843:189728-190129 [Burkholderia ambifaria]
MPRYMLDTNMCIYLMKNQPEQVATRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRHLAALIDDIPVAPFDVAAAQA
YGPVREATRERKKDHLDKLIAAHAVSLDVVLVTNNERDFVSYPGLRLENWLND

Download         Length: 402 bp

>T237247 NZ_LR822061:c174760-174665 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8982.04 Da        Isoelectric Point: 5.1473

>AT237247 WP_126228768.1 NZ_CP092843:189492-189728 [Burkholderia ambifaria]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPTRQPLTHVLEKFAKFGPDFMAEGRGDQEQADREGL

Download         Length: 237 bp

>AT237247 NZ_LR822061:174580-174637 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References