Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 1953627..1954138 Replicon chromosome
Accession NZ_CP092832
Organism Flavobacterium sp. HJ-32-4

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MKO97_RS08075 Protein ID WP_241102702.1
Coordinates 1953881..1954138 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag MKO97_RS08070 Protein ID WP_241102701.1
Coordinates 1953627..1953881 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKO97_RS08045 (MKO97_08045) 1948808..1950103 + 1296 WP_241102696.1 anthranilate synthase component I family protein -
MKO97_RS08050 (MKO97_08050) 1950207..1950797 + 591 WP_241102697.1 peptide deformylase -
MKO97_RS08055 (MKO97_08055) 1950812..1951240 + 429 WP_241102698.1 DUF5606 domain-containing protein -
MKO97_RS08060 (MKO97_08060) 1951576..1952346 + 771 WP_241102699.1 nucleoside triphosphate pyrophosphohydrolase -
MKO97_RS08065 (MKO97_08065) 1952644..1953171 - 528 WP_241102700.1 hypothetical protein -
MKO97_RS08070 (MKO97_08070) 1953627..1953881 + 255 WP_241102701.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
MKO97_RS08075 (MKO97_08075) 1953881..1954138 + 258 WP_241102702.1 Txe/YoeB family addiction module toxin Toxin
MKO97_RS08080 (MKO97_08080) 1954265..1955695 + 1431 WP_241102703.1 amino acid permease -
MKO97_RS08085 (MKO97_08085) 1955795..1958239 + 2445 WP_241102704.1 heavy metal translocating P-type ATPase metal-binding domain-containing protein -
MKO97_RS08090 (MKO97_08090) 1958249..1958434 + 186 WP_241102705.1 cbb3-type cytochrome oxidase assembly protein CcoS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10662.16 Da        Isoelectric Point: 8.7795

>T237243 WP_241102702.1 NZ_CP092832:1953881-1954138 [Flavobacterium sp. HJ-32-4]
MRYVFVDESWEDYLYWQKIDKKKVKRINDLLKDIARSPFEGIGKPEPLKHKYSGFWSRRIDEEHRLIYRYQDDEIQIVKC
RHHYD

Download         Length: 258 bp

>T237243 NZ_LR822060:2868470-2868679 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9652.98 Da        Isoelectric Point: 5.1726

>AT237243 WP_241102701.1 NZ_CP092832:1953627-1953881 [Flavobacterium sp. HJ-32-4]
MFVANISEFRKDIKSYLDRVAKNFETLIINRGKDSGIVVMSLEEYNSLMATSYELSSRANEKRLDSAIEKLRNGKAFDKD
LIED

Download         Length: 255 bp

>AT237243 NZ_LR822060:2868165-2868458 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References