Detailed information of TA system TA237242

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pemK-mazE/MazF(toxin)
• Location: 1510843..1511481
• Replicon: chromosome
• Accession: NZ_CP092831
• Organism: Paenibacillus peoriae strain ZBSF16

Toxin (Protein)

• Gene name: pemK
• Uniprot ID: H6CFY1
• Locus tag: MLD56_RS06750
• Protein ID: WP_007429335.1
• Coordinates: 1511131..1511481 (+)
• Length: 117 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H6CFY0
• Locus tag: MLD56_RS06745
• Protein ID: WP_007429334.1
• Coordinates: 1510843..1511124 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLD56_RS06730 (MLD56_06730)	1507066..1507697	+	632	Protein_1278	LysE family transporter	-
MLD56_RS06735 (MLD56_06735)	1507808..1509085	+	1278	WP_029516342.1	outer membrane lipoprotein-sorting protein	-
MLD56_RS06740 (MLD56_06740)	1509355..1510551	+	1197	WP_029516343.1	alanine racemase	-
MLD56_RS06745 (MLD56_06745)	1510843..1511124	+	282	WP_007429334.1	ribbon-helix-helix protein, CopG family	Antitoxin
MLD56_RS06750 (MLD56_06750)	1511131..1511481	+	351	WP_007429335.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MLD56_RS06755 (MLD56_06755)	1511661..1513883	+	2223	WP_029516344.1	Tex family protein	-
MLD56_RS06760 (MLD56_06760)	1513988..1514122	-	135	WP_007429337.1	cortex morphogenetic protein CmpA	-
MLD56_RS06765 (MLD56_06765)	1514267..1514791	+	525	WP_029516345.1	SprT family protein	-
MLD56_RS06780 (MLD56_06780)	1515181..1516056	-	876	WP_029516346.1	Cof-type HAD-IIB family hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (4-111)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 117 a.a.
• Molecular weight: 12822.77 Da
• Isoelectric Point: 5.6195

>T237242 WP_007429335.1 NZ_CP092831:1511131-1511481 [Paenibacillus peoriae]
MIVKRGDVFFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAATHGFDRDSVVLLEQI
RTIDKQRLTDKITHLDEETMRKVSDSLQISLGLIDF

Nucleotide

• Length: 351 bp

>T237242 NZ_LR822060:2785446-2785682 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10636.25 Da
• Isoelectric Point: 8.5257

>AT237242 WP_007429334.1 NZ_CP092831:1510843-1511124 [Paenibacillus peoriae]
MANLQNTKRIMISLPDHLLQEVDGIVAMENSNRSEFIRQAMKLYVGERKKRYIREAMQRGYMEMAKINLTMASEAFHAEE
DANSTLGRTVSGV

Nucleotide

• Length: 282 bp

>AT237242 NZ_LR822060:2785687-2785869 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Structures

Toxin

• AlphaFold DB: H6CFY1

Antitoxin

• AlphaFold DB: H6CFY0