Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 6500979..6502519 Replicon chromosome
Accession NZ_CP092830
Organism Pseudomonas azotoformans strain ZY-1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MLC69_RS29745 Protein ID WP_078051009.1
Coordinates 6501245..6502519 (-) Length 425 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MLC69_RS29740 Protein ID WP_078050791.1
Coordinates 6500979..6501248 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLC69_RS29720 (MLC69_29720) 6497368..6498915 - 1548 WP_078050787.1 PLP-dependent aminotransferase family protein -
MLC69_RS29725 (MLC69_29725) 6499003..6499641 + 639 WP_078050788.1 FMN-binding negative transcriptional regulator -
MLC69_RS29730 (MLC69_29730) 6499638..6500084 + 447 WP_078050789.1 GNAT family N-acetyltransferase -
MLC69_RS29735 (MLC69_29735) 6500095..6500766 + 672 WP_078050790.1 GNAT family protein -
MLC69_RS29740 (MLC69_29740) 6500979..6501248 - 270 WP_078050791.1 helix-turn-helix transcriptional regulator Antitoxin
MLC69_RS29745 (MLC69_29745) 6501245..6502519 - 1275 WP_078051009.1 HipA domain-containing protein Toxin
MLC69_RS29750 (MLC69_29750) 6502871..6504145 + 1275 WP_078050792.1 autotransporter outer membrane beta-barrel domain-containing protein -
MLC69_RS29755 (MLC69_29755) 6504235..6506043 - 1809 WP_078050793.1 sodium-extruding oxaloacetate decarboxylase subunit alpha -
MLC69_RS29760 (MLC69_29760) 6506055..6507470 - 1416 WP_003195732.1 acetyl-CoA carboxylase biotin carboxylase subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-349)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-82)


Sequences

Toxin        


Download         Length: 425 a.a.        Molecular weight: 47125.44 Da        Isoelectric Point: 5.5952

>T237241 WP_078051009.1 NZ_CP092830:c6502519-6501245 [Pseudomonas azotoformans]
MTLEFSEPDKGFASPCRFGYESDYLVDHLDHIDTVFAKAVSVRVPLNWAQEAPRNAPAFLHDIAPAGAAKRFLASRFEML
STDNVSSDLFLLARSTPAPIGHMRIKESLQALNDRPPMGFERQEVIDRDNRFLEYAYEQGAAIGGATGAGGEAPKLLLTQ
SHEGLLYPDAVLGDDQASQHWFIKFARNQGLQIDQDILRSEFHYYKALQSLGIETVAVEGLALEMATKPSLWMHRFDRHV
SDQGVERFAVESIYSLAGVTKPGSAMSHLDVLLQLAGLWQQAGQGEQLTDLVADYLRRDLLNKVLGNSDNHGRNTSIIRG
PDSLRLAPIYDLAPMVMDPEGVTRTTKWPRPLEIAGDIDWRGVCNALAPVINPTDAFERLRTDAQRLRALPDILVDSGLP
KVTLNHPSIALRNLDQRLRSWGLQ

Download         Length: 1275 bp

>T237241 NZ_LR822060:2766615-2766719 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9877.51 Da        Isoelectric Point: 10.9066

>AT237241 WP_078050791.1 NZ_CP092830:c6501248-6500979 [Pseudomonas azotoformans]
MSLSMSQRAQVIESIEQGLSDGSLEIGDAVRRLRTEVTGLHQAQFAKMCKISVRTLVHIEHGEGNQTLKSLNAVFRPFGL
KMGVVKVRR

Download         Length: 270 bp

>AT237241 NZ_LR822060:c2766877-2766714 [Staphylococcus aureus]
GTAGTAAGTAGAAGCAAAAGATGAAAATCTTTAACTCTTGAAACACAAAAAGGGCAACACTCGGAAACATGTTACCCTAA
TGAGCCCGTTAAAAAGACGGTGACCTTATATTTTATTTAAAAATAGCCTTCAAAATGCCGGTCAAAGCGAATAGAAGGTT
ATTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References