Detailed information of TA system TA237240

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA(toxin)
• Location: 2498644..2499257
• Replicon: chromosome
• Accession: NZ_CP092830
• Organism: Pseudomonas azotoformans strain ZY-1

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: MLC69_RS11525
• Protein ID: WP_078047964.1
• Coordinates: 2499006..2499257 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: MLC69_RS11520
• Protein ID: WP_078047963.1
• Coordinates: 2498644..2499009 (-)
• Length: 122 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MLC69_RS11500 (MLC69_11500)	2494382..2495365	+	984	WP_078047959.1	AAA family ATPase	-
MLC69_RS11505 (MLC69_11505)	2495403..2496758	+	1356	WP_078047960.1	MATE family efflux transporter	-
MLC69_RS11510 (MLC69_11510)	2496742..2497329	-	588	WP_078047961.1	TetR/AcrR family transcriptional regulator	-
MLC69_RS11515 (MLC69_11515)	2497471..2498643	+	1173	WP_078047962.1	MFS transporter	-
MLC69_RS11520 (MLC69_11520)	2498644..2499009	-	366	WP_078047963.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
MLC69_RS11525 (MLC69_11525)	2499006..2499257	-	252	WP_078047964.1	type II toxin-antitoxin system HicA family toxin	Toxin

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (20-76)

Antitoxin

• Uncharacterised protein family HicB (55-105)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9488.02 Da
• Isoelectric Point: 10.0459

>T237240 WP_078047964.1 NZ_CP092830:c2499257-2499006 [Pseudomonas azotoformans]
VSKNEKLLAKLLNEHTAFTWPELVTLLRRLGYTQIEGAGSRVKFDIGDPSAMITLHKPHPGNELKHYIRRQIIEQLKSGE
LIQ

Nucleotide

• Length: 252 bp

>T237240 NZ_LR822060:2506993-2507259 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 122 a.a.
• Molecular weight: 13150.92 Da
• Isoelectric Point: 6.6267

>AT237240 WP_078047963.1 NZ_CP092830:c2499009-2498644 [Pseudomonas azotoformans]
VNNQLQHKGYIGSIEASLEDNCLFGKILFIKALVSYEGKTVAELDGAFREAVDDYLATCQALGQTPEKPCKGSFNVRVGH
DLHLAAALAATRKKVTLNDLTRQALNEFLQHHGNDPCPAVS

Nucleotide

• Length: 366 bp

>AT237240 NZ_LR822060:2506742-2506993 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA