Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2038538..2039142 Replicon chromosome
Accession NZ_CP092830
Organism Pseudomonas azotoformans strain ZY-1

Toxin (Protein)


Gene name hicA Uniprot ID A0A1U9PV57
Locus tag MLC69_RS09300 Protein ID WP_073859991.1
Coordinates 2038538..2038726 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MLC69_RS09305 Protein ID WP_078047607.1
Coordinates 2038738..2039142 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLC69_RS09275 (MLC69_09275) 2034228..2034947 + 720 WP_078047602.1 phosphonate C-P lyase system protein PhnL -
MLC69_RS09280 (MLC69_09280) 2034937..2036082 + 1146 WP_078047603.1 alpha-D-ribose 1-methylphosphonate 5-triphosphate diphosphatase -
MLC69_RS09285 (MLC69_09285) 2036082..2036654 + 573 WP_078047604.1 phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN -
MLC69_RS09290 (MLC69_09290) 2036645..2037394 + 750 WP_078047605.1 phosphonate metabolism protein PhnP -
MLC69_RS09295 (MLC69_09295) 2037477..2038355 - 879 WP_078047606.1 LysR family transcriptional regulator -
MLC69_RS09300 (MLC69_09300) 2038538..2038726 + 189 WP_073859991.1 type II toxin-antitoxin system HicA family toxin Toxin
MLC69_RS09305 (MLC69_09305) 2038738..2039142 + 405 WP_078047607.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
MLC69_RS09310 (MLC69_09310) 2039536..2041065 + 1530 WP_078047608.1 M10 family metallopeptidase C-terminal domain-containing protein -
MLC69_RS09315 (MLC69_09315) 2041308..2043041 + 1734 WP_078047609.1 M10 family metallopeptidase C-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7192.39 Da        Isoelectric Point: 11.2000

>T237239 WP_073859991.1 NZ_CP092830:2038538-2038726 [Pseudomonas azotoformans]
VQSRLLIKELQEAGWVLDRVTGSHHIFTHRYSPYTLPVPHPKKDLPLGTVRSIRKRAGLFQF

Download         Length: 189 bp

>T237239 NZ_LR822060:2481579-2481686 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14745.73 Da        Isoelectric Point: 4.4776

>AT237239 WP_078047607.1 NZ_CP092830:2038738-2039142 [Pseudomonas azotoformans]
MQYPICIEWGDDFTATGIQIPDIPGAVTAGDSFEEAYNAAVEVAHIMLQEIAAEGGTIPMPTSVAQYHAHEDYAGMGWGM
LELDVTPYLGKTEKVNVTLPGYVIQRIDRYVREHKVKSRSSFLADAALEKLVRS

Download         Length: 405 bp

>AT237239 NZ_LR822060:c2481763-2481703 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1U9PV57

Antitoxin

Source ID Structure

References