Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4403157..4403776 Replicon chromosome
Accession NZ_CP092828
Organism Klebsiella michiganensis strain HOBD-7

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag MJ905_RS20635 Protein ID WP_004099646.1
Coordinates 4403157..4403375 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID H3N7X7
Locus tag MJ905_RS20640 Protein ID WP_004129911.1
Coordinates 4403402..4403776 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ905_RS20600 (MJ905_20595) 4399202..4399465 + 264 WP_004848323.1 type B 50S ribosomal protein L31 -
MJ905_RS20605 (MJ905_20600) 4399465..4399605 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
MJ905_RS20610 (MJ905_20605) 4399602..4400300 - 699 WP_014228203.1 GNAT family protein -
MJ905_RS20615 (MJ905_20610) 4400402..4401856 + 1455 WP_038424163.1 PLP-dependent aminotransferase family protein -
MJ905_RS20620 (MJ905_20615) 4401831..4402301 - 471 WP_014228205.1 YlaC family protein -
MJ905_RS20625 (MJ905_20620) 4402322..4402456 + 135 WP_223226764.1 hypothetical protein -
MJ905_RS20630 (MJ905_20625) 4402428..4402994 - 567 WP_038424164.1 maltose O-acetyltransferase -
MJ905_RS20635 (MJ905_20630) 4403157..4403375 - 219 WP_004099646.1 HHA domain-containing protein Toxin
MJ905_RS20640 (MJ905_20635) 4403402..4403776 - 375 WP_004129911.1 Hha toxicity modulator TomB Antitoxin
MJ905_RS20645 (MJ905_20640) 4404257..4407403 - 3147 WP_014228207.1 multidrug efflux RND transporter permease subunit AcrB -
MJ905_RS20650 (MJ905_20645) 4407426..4408619 - 1194 WP_004136054.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T237237 WP_004099646.1 NZ_CP092828:c4403375-4403157 [Klebsiella michiganensis]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

>T237237 NZ_LR822060:1278553-1278741 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT237237 WP_004129911.1 NZ_CP092828:c4403776-4403402 [Klebsiella michiganensis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLITQIDEYL
DDTFVLFSNYGINSADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT237237 NZ_LR822060:1278264-1278524 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3HD25

References