Detailed information of TA system TA237236

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4179250..4180069
• Replicon: chromosome
• Accession: NZ_CP092828
• Organism: Klebsiella michiganensis strain HOBD-7

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: MJ905_RS19575
• Protein ID: WP_004110819.1
• Coordinates: 4179250..4179507 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: MJ905_RS19580
• Protein ID: WP_255850367.1
• Coordinates: 4179518..4180069 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ905_RS19560 (MJ905_19555)	4174926..4175702	-	777	WP_004847986.1	Uxu operon transcriptional regulator	-
MJ905_RS19565 (MJ905_19560)	4175841..4177316	-	1476	WP_014228053.1	fructuronate reductase	-
MJ905_RS19570 (MJ905_19565)	4177390..4178574	-	1185	WP_014228054.1	mannonate dehydratase	-
MJ905_RS19575 (MJ905_19570)	4179250..4179507	+	258	WP_004110819.1	YjhX family toxin	Toxin
MJ905_RS19580 (MJ905_19575)	4179518..4180069	+	552	WP_255850367.1	N-acetyltransferase	Antitoxin
MJ905_RS19585 (MJ905_19580)	4180183..4180545	+	363	Protein_3816	class I SAM-dependent methyltransferase	-
MJ905_RS19590 (MJ905_19585)	4180969..4181715	+	747	WP_014228056.1	class I SAM-dependent methyltransferase	-
MJ905_RS19595 (MJ905_19590)	4181930..4182817	-	888	WP_255850368.1	EamA family transporter	-
MJ905_RS19600 (MJ905_19595)	4182937..4183845	+	909	WP_032693197.1	transcriptional regulator GcvA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T237236 WP_004110819.1 NZ_CP092828:4179250-4179507 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T237236 NZ_LR822060:c1003455-1003219 [Staphylococcus aureus]
ATGAATAACCGCGAACAAATCGAACAGTCCGTTATAAGTGCTAGTGCGTATAACGGCAATGACACAGAGGGATTACTAAA
AGAGATTGAAGACGTGTATAAGAAAGCACAAGCGTTTGATGAAATACTTGAGGGAATGACAAATGCTATTCAACATTCAG
TTAAAGAAGGTATTGAACTTGATGAAGCAGTAGGGATTATGGCAGGTCAAGTTGTCTATAAATATGAGGAGGAATAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19977.77 Da
• Isoelectric Point: 6.6519

>AT237236 WP_255850367.1 NZ_CP092828:4179518-4180069 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQRLSS
QPLGRAGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT237236 NZ_LR822060:c1003214-1003032 [Staphylococcus aureus]
ATGAGCATTAGTGTAGGAGACAAGGTTTTTAATCCAGAAACAAATTCAACTTTAGAAATTGTACAACTTGTTGGCGATAT
TAGAGACACGCATTACAAGTTATCTGACGGATCTATTATTAGTCTTATAGACTTTGTTGTTAAACCAATTCATTTAATCA
AGGAGGCACAGGAAAATGACTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2