Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2139860..2140517 Replicon chromosome
Accession NZ_CP092828
Organism Klebsiella michiganensis strain HOBD-7

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag MJ905_RS10020 Protein ID WP_004854060.1
Coordinates 2139860..2140270 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag MJ905_RS10025 Protein ID WP_004124953.1
Coordinates 2140251..2140517 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MJ905_RS10000 (MJ905_09995) 2135837..2137570 - 1734 WP_038423602.1 single-stranded-DNA-specific exonuclease RecJ -
MJ905_RS10005 (MJ905_10000) 2137576..2138289 - 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MJ905_RS10010 (MJ905_10005) 2138312..2139208 - 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
MJ905_RS10015 (MJ905_10010) 2139330..2139851 + 522 WP_014226792.1 flavodoxin FldB -
MJ905_RS10020 (MJ905_10015) 2139860..2140270 - 411 WP_004854060.1 protein YgfX Toxin
MJ905_RS10025 (MJ905_10020) 2140251..2140517 - 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
MJ905_RS10030 (MJ905_10025) 2140762..2141745 + 984 WP_032720095.1 tRNA-modifying protein YgfZ -
MJ905_RS10035 (MJ905_10030) 2141939..2144737 + 2799 WP_128696508.1 transcriptional regulator DagR -
MJ905_RS10040 (MJ905_10035) 2144858..2145283 + 426 WP_032720093.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T237232 WP_004854060.1 NZ_CP092828:c2140270-2139860 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

>T237232 NZ_LR822060:18786-18962 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT237232 WP_004124953.1 NZ_CP092828:c2140517-2140251 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT237232 NZ_LR822060:c19124-18950 [Staphylococcus aureus]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References