Detailed information of TA system TA237231

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 1669988..1670771
• Replicon: chromosome
• Accession: NZ_CP092828
• Organism: Klebsiella michiganensis strain HOBD-7

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: -
• Locus tag: MJ905_RS07780
• Protein ID: WP_111965506.1
• Coordinates: 1670397..1670771 (+)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: MJ905_RS07775
• Protein ID: WP_252052494.1
• Coordinates: 1669988..1670347 (+)
• Length: 120 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ905_RS07740 (MJ905_07735)	1666345..1666809	+	465	WP_004114621.1	hypothetical protein	-
MJ905_RS07745 (MJ905_07740)	1666864..1667223	+	360	WP_004136901.1	hypothetical protein	-
MJ905_RS07750 (MJ905_07745)	1667308..1667520	+	213	WP_252052500.1	hypothetical protein	-
MJ905_RS07755 (MJ905_07750)	1667627..1668448	+	822	WP_252052499.1	DUF932 domain-containing protein	-
MJ905_RS07760 (MJ905_07755)	1668528..1669007	+	480	WP_252052498.1	antirestriction protein	-
MJ905_RS07765 (MJ905_07760)	1669248..1669730	+	483	WP_047058008.1	DNA repair protein RadC	-
MJ905_RS07770 (MJ905_07765)	1669744..1669965	+	222	WP_032938028.1	DUF987 domain-containing protein	-
MJ905_RS07775 (MJ905_07770)	1669988..1670347	+	360	WP_252052494.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
MJ905_RS07780 (MJ905_07775)	1670397..1670771	+	375	WP_111965506.1	TA system toxin CbtA family protein	Toxin
MJ905_RS07785 (MJ905_07780)	1670910..1671302	-	393	WP_252052493.1	hypothetical protein	-
MJ905_RS07790 (MJ905_07785)	1671306..1672295	-	990	WP_252052491.1	glycosyltransferase	-
MJ905_RS07795 (MJ905_07790)	1673069..1673977	-	909	WP_015705671.1	kdo(2)-lipid IV(A) palmitoleoyltransferase	-
MJ905_RS07800 (MJ905_07795)	1674179..1674451	-	273	WP_171279005.1	hypothetical protein	-
MJ905_RS07805 (MJ905_07800)	1674861..1675094	+	234	WP_252052525.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1645152..1675094	29942

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (15-114)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14023.19 Da
• Isoelectric Point: 10.0009

>T237231 WP_111965506.1 NZ_CP092828:1670397-1670771 [Klebsiella michiganensis]
MQTQSRPPQRAASPLLSLIEIWQKLLEYLLKQHYGLMLNDTPFGNDEVIQKHIEAGISLCDAVNFIVEKYDLVRTDRHGF
SVKEQSPFIGSIDMLRARKATGLMTRKGYKTVTDITGGRSSRGK

Nucleotide

• Length: 375 bp

>T237231 NZ_LR822035:674043-674408 [Streptococcus thermophilus]
GTGCACGCTATTTATTTTTATAAGGACAAACAGGGGAATCAACCGGTCTTGGACTACATGAGAGAGCTAGCTCGTCACGA
TAGCAAGGACAGCCGGATCAAACTCAACAAGCTCAACGACTACATCGAACTTTTGAGCCAACATGGTACCTGTGCTGGCC
AACCCTATATCAAGCATCTGGATGCGGAGATTTGGGAGTTGAGACCCTTGCGGGATCGGATTTTATTCGTGGCTTGGTTG
GATGGAAGCTTTGTCTTACTGCATCATTTTGTCAAAAAGACGCAAAAGACACCTAGACGAGAGATCGAGAAAGCCAAGCG
GGAGTTGCAAGATTTGAAGGAAAGAGGGCTAAGAGATGAAGAATAG

Antitoxin

Protein

• Length: 120 a.a.
• Molecular weight: 13423.62 Da
• Isoelectric Point: 8.8636

>AT237231 WP_252052494.1 NZ_CP092828:1669988-1670347 [Klebsiella michiganensis]
MQKATRVINHNIAEPWWGLRRNVTPCFGARLVQEGNRLHYLADRASTTGTFNDTDLRHLDQAFPLLMKQMELMLTSSELM
PRIQRCITLHAKGLICKADTLGSCGYLYIVIYPASATTA

Nucleotide

• Length: 360 bp

>AT237231 NZ_LR822035:674398-674691 [Streptococcus thermophilus]
ATGAAGAATAGTGCCATCGGCAGCAATTGGAAAGATGTGAGAGCAGAGCTCTTCACAAAGGAAGAAATCCTGGAAAGTGA
TCTGCGGGTCGCGATTATGACGGAGCTAATCGAGGCTCGGCATGAAAAGGGCTTTAGCCAAAAGAAACTAGAAGAACTCA
GTGGGGTCAGTCAACCGGTCATCGCTCGGATGGAGACGGGAAAGACCAGTCCTCAATTGGACACGGTCTTGAAAGTCTTA
GCCAGTCTGGGCAAGACCCTTGCTGTCGTCCCACTGGAACAAGAAAAGCTCTAA