Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 241541..242183 Replicon chromosome
Accession NC_012581
Organism Bacillus anthracis str. CDC 684

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag BAMEG_RS01850 Protein ID WP_000635963.1
Coordinates 241833..242183 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag BAMEG_RS01845 Protein ID WP_000004570.1
Coordinates 241541..241828 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMEG_RS01820 236857..237819 + 963 WP_000961037.1 UV DNA damage repair endonuclease UvsE -
BAMEG_RS01825 237812..238384 - 573 WP_000906916.1 rhomboid family intramembrane serine protease -
BAMEG_RS01830 238477..238836 + 360 WP_000635040.1 holo-ACP synthase -
BAMEG_RS01835 238993..239943 + 951 WP_025388382.1 outer membrane lipoprotein carrier protein LolA -
BAMEG_RS01840 240062..241231 + 1170 WP_000390596.1 alanine racemase -
BAMEG_RS01845 241541..241828 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
BAMEG_RS01850 241833..242183 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
BAMEG_RS01855 242251..244419 + 2169 WP_000426225.1 RNA-binding transcriptional accessory protein -
BAMEG_RS01860 244477..244593 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
BAMEG_RS01865 244789..245247 + 459 WP_000344248.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T23722 WP_000635963.1 NC_012581:241833-242183 [Bacillus anthracis str. CDC 684]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

>T23722 NC_012581:241833-242183 [Bacillus anthracis str. CDC 684]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGTGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT23722 WP_000004570.1 NC_012581:241541-241828 [Bacillus anthracis str. CDC 684]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp

>AT23722 NC_012581:241541-241828 [Bacillus anthracis str. CDC 684]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References