Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3911229..3912423 Replicon chromosome
Accession NZ_CP092827
Organism Pseudomonas sp. LS.1a

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MKK04_RS18185 Protein ID WP_241105859.1
Coordinates 3911857..3912423 (+) Length 189 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MKK04_RS18180 Protein ID WP_233686993.1
Coordinates 3911229..3911792 (+) Length 188 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MKK04_RS18165 (MKK04_18165) 3907291..3908364 + 1074 WP_009686399.1 microcin C ABC transporter permease YejB -
MKK04_RS18170 (MKK04_18170) 3908366..3909385 + 1020 WP_063912689.1 ABC transporter permease -
MKK04_RS18175 (MKK04_18175) 3909387..3910997 + 1611 WP_063912690.1 ABC transporter ATP-binding protein -
MKK04_RS18180 (MKK04_18180) 3911229..3911792 + 564 WP_233686993.1 helix-turn-helix transcriptional regulator Antitoxin
MKK04_RS18185 (MKK04_18185) 3911857..3912423 + 567 WP_241105859.1 HD domain-containing protein Toxin
MKK04_RS18190 (MKK04_18190) 3912420..3912878 - 459 WP_207831272.1 hypothetical protein -
MKK04_RS18195 (MKK04_18195) 3913087..3916017 + 2931 WP_241105860.1 aminotransferase -
MKK04_RS18200 (MKK04_18200) 3916381..3917286 + 906 WP_241105861.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3891414..3916017 24603


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-166)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-63)


Sequences

Toxin        


Download         Length: 189 a.a.        Molecular weight: 21136.92 Da        Isoelectric Point: 5.3404

>T237219 WP_241105859.1 NZ_CP092827:3911857-3912423 [Pseudomonas sp. LS.1a]
VPNHNLHGKLEFLRQAEKLKSVTRSAHTSTGRRESTAEHSWRLALLALVFEEELGDVDICKVLKLCLVHDLGEALSGDVP
APQAQATPNKSMSERQDLISMTSMLEPSMQDNIVALFDEYEAADSPEAKVVKALDKIETILQHTQGDNPPGFDYAFNLEY
GRRYTDALPFLASLRRTLDEETRKRMAR

Download         Length: 567 bp

>T237219 NZ_LR796240:c2521289-2520978 [Treponema socranskii subsp. buccale]
ATGGTTTACAATACAAGTGTGAACTATGAAGTAAGGCAGACAGAAGAATTTTCAAAATGGCTTAAAAAACTGAAAGATGC
CGTTGCAAAAGTAGCGATAGCAAGGCGGATTGACAGAATGAAAGAGGGCAATTTCGGAGACTCAAAGTCGGTCGGCGGCG
AAGTGTTTGAACTAAGGATTGATGTGGGCAAGGGCTACCGTGTTTACTTTACAAACAAAAATAACAAGATCGTGATACTT
CTTGTAGGCGGTGATAAATCTACACAGGATGAGGATATAAAGATCGCCAAGAAAATGGTTAAGGAGATTTAA

Antitoxin


Download         Length: 188 a.a.        Molecular weight: 20502.32 Da        Isoelectric Point: 7.4186

>AT237219 WP_233686993.1 NZ_CP092827:3911229-3911792 [Pseudomonas sp. LS.1a]
ISPSLRNTPIGPMLKHWRVLNRVKQLHAAQMFGVCQSTISRWESGVQDAEPEQRARIEALLKARLSSAADHALARLVSGS
SQPVHLVCDLTHRLLACSSSREAEFSVPVSDLLGVSLWPFATEEIASQEQRLAGIGWRDNLASPALEFSTGTNDSAVVPI
QHSLCRWTRFTLSDGSTARLVETLAHI

Download         Length: 564 bp

>AT237219 NZ_LR796240:c2520976-2520683 [Treponema socranskii subsp. buccale]
ATGTTGAAAACTACGGAATTTGATATTGCTGAATATCTCGACACGGAAGAATTAAGAGAAGGCTACCTTGAACTTGTTGC
AAAGGACGGCACACAAGAGGAATTGCTCCGTGCAATAAACGCAGTGGCAAGGGCAAGGGGAATGACAGAGACCGCAAAGG
AAGCGGGGATTACACGGGAGGGTCTGTATAAGGCACTTTCCCCGAACGGAAATCCTACATTCTCAACCGTTTGGAACGTT
CTCCACGCTATCGGTTATACACTCACGCCTACACCGATAGCAAAAACGATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References