Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 3590693..3591346 | Replicon | chromosome |
| Accession | NZ_CP092827 | ||
| Organism | Pseudomonas sp. LS.1a | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | MKK04_RS16475 | Protein ID | WP_241105720.1 |
| Coordinates | 3590693..3590878 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | MKK04_RS16480 | Protein ID | WP_241105721.1 |
| Coordinates | 3590924..3591346 (+) | Length | 141 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MKK04_RS16450 (MKK04_16450) | 3586264..3587643 | - | 1380 | WP_241105714.1 | DUF4055 domain-containing protein | - |
| MKK04_RS16455 (MKK04_16455) | 3587646..3588926 | - | 1281 | WP_241105715.1 | terminase family protein | - |
| MKK04_RS16460 (MKK04_16460) | 3588901..3589548 | - | 648 | WP_241105717.1 | terminase small subunit | - |
| MKK04_RS16465 (MKK04_16465) | 3590018..3590287 | - | 270 | WP_241105718.1 | hypothetical protein | - |
| MKK04_RS16470 (MKK04_16470) | 3590287..3590598 | - | 312 | WP_016711287.1 | hypothetical protein | - |
| MKK04_RS16475 (MKK04_16475) | 3590693..3590878 | + | 186 | WP_241105720.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| MKK04_RS16480 (MKK04_16480) | 3590924..3591346 | + | 423 | WP_241105721.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| MKK04_RS16485 (MKK04_16485) | 3591713..3592249 | - | 537 | WP_241105722.1 | hypothetical protein | - |
| MKK04_RS26505 | 3592246..3592368 | - | 123 | WP_272493113.1 | hypothetical protein | - |
| MKK04_RS16490 (MKK04_16490) | 3592365..3592724 | - | 360 | WP_241105723.1 | endodeoxyribonuclease RusA | - |
| MKK04_RS16495 (MKK04_16495) | 3592721..3593023 | - | 303 | WP_241105724.1 | DUF1364 family protein | - |
| MKK04_RS16500 (MKK04_16500) | 3593014..3593337 | - | 324 | WP_241105725.1 | hypothetical protein | - |
| MKK04_RS16505 (MKK04_16505) | 3593334..3593804 | - | 471 | WP_241105726.1 | hypothetical protein | - |
| MKK04_RS16510 (MKK04_16510) | 3593801..3594019 | - | 219 | WP_241105727.1 | hypothetical protein | - |
| MKK04_RS16515 (MKK04_16515) | 3594016..3594777 | - | 762 | WP_241105728.1 | replication protein P | - |
| MKK04_RS16520 (MKK04_16520) | 3594774..3595517 | - | 744 | WP_241105729.1 | helix-turn-helix domain-containing protein | - |
| MKK04_RS16525 (MKK04_16525) | 3595514..3595984 | - | 471 | WP_241105730.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 3563130..3634351 | 71221 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 6906.11 Da Isoelectric Point: 10.8181
>T237218 WP_241105720.1 NZ_CP092827:3590693-3590878 [Pseudomonas sp. LS.1a]
MKCNEFKRWLLARGVEVSKTAKGSHFKLYFNGKQTTLPNHGAKEMAEGTRKAIIKQLGLKD
MKCNEFKRWLLARGVEVSKTAKGSHFKLYFNGKQTTLPNHGAKEMAEGTRKAIIKQLGLKD
Download Length: 186 bp
>T237218 NZ_LR796240:c2520976-2520683 [Treponema socranskii subsp. buccale]
ATGTTGAAAACTACGGAATTTGATATTGCTGAATATCTCGACACGGAAGAATTAAGAGAAGGCTACCTTGAACTTGTTGC
AAAGGACGGCACACAAGAGGAATTGCTCCGTGCAATAAACGCAGTGGCAAGGGCAAGGGGAATGACAGAGACCGCAAAGG
AAGCGGGGATTACACGGGAGGGTCTGTATAAGGCACTTTCCCCGAACGGAAATCCTACATTCTCAACCGTTTGGAACGTT
CTCCACGCTATCGGTTATACACTCACGCCTACACCGATAGCAAAAACGATGTAA
ATGTTGAAAACTACGGAATTTGATATTGCTGAATATCTCGACACGGAAGAATTAAGAGAAGGCTACCTTGAACTTGTTGC
AAAGGACGGCACACAAGAGGAATTGCTCCGTGCAATAAACGCAGTGGCAAGGGCAAGGGGAATGACAGAGACCGCAAAGG
AAGCGGGGATTACACGGGAGGGTCTGTATAAGGCACTTTCCCCGAACGGAAATCCTACATTCTCAACCGTTTGGAACGTT
CTCCACGCTATCGGTTATACACTCACGCCTACACCGATAGCAAAAACGATGTAA
Antitoxin
Download Length: 141 a.a. Molecular weight: 15279.43 Da Isoelectric Point: 5.2293
>AT237218 WP_241105721.1 NZ_CP092827:3590924-3591346 [Pseudomonas sp. LS.1a]
MYDYAINVNQEAGSFWSSCDDIPEAHSAGDTLEELLRHAAEGLEVALSIYVDQLRPIPPASPAKEGQHVIRLSALVNAKI
ALWNAMREKGMRKADLCRTLGAVQTKVDRLLDFEHSSKIEQVEAALAALGKRLVVSAEPA
MYDYAINVNQEAGSFWSSCDDIPEAHSAGDTLEELLRHAAEGLEVALSIYVDQLRPIPPASPAKEGQHVIRLSALVNAKI
ALWNAMREKGMRKADLCRTLGAVQTKVDRLLDFEHSSKIEQVEAALAALGKRLVVSAEPA
Download Length: 423 bp
>AT237218 NZ_LR796240:c2521289-2520978 [Treponema socranskii subsp. buccale]
ATGGTTTACAATACAAGTGTGAACTATGAAGTAAGGCAGACAGAAGAATTTTCAAAATGGCTTAAAAAACTGAAAGATGC
CGTTGCAAAAGTAGCGATAGCAAGGCGGATTGACAGAATGAAAGAGGGCAATTTCGGAGACTCAAAGTCGGTCGGCGGCG
AAGTGTTTGAACTAAGGATTGATGTGGGCAAGGGCTACCGTGTTTACTTTACAAACAAAAATAACAAGATCGTGATACTT
CTTGTAGGCGGTGATAAATCTACACAGGATGAGGATATAAAGATCGCCAAGAAAATGGTTAAGGAGATTTAA
ATGGTTTACAATACAAGTGTGAACTATGAAGTAAGGCAGACAGAAGAATTTTCAAAATGGCTTAAAAAACTGAAAGATGC
CGTTGCAAAAGTAGCGATAGCAAGGCGGATTGACAGAATGAAAGAGGGCAATTTCGGAGACTCAAAGTCGGTCGGCGGCG
AAGTGTTTGAACTAAGGATTGATGTGGGCAAGGGCTACCGTGTTTACTTTACAAACAAAAATAACAAGATCGTGATACTT
CTTGTAGGCGGTGATAAATCTACACAGGATGAGGATATAAAGATCGCCAAGAAAATGGTTAAGGAGATTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|