Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2109066..2109580 Replicon chromosome
Accession NZ_CP092825
Organism Staphylococcus aureus strain GY8

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag MK796_RS10370 Protein ID WP_000581792.1
Coordinates 2109066..2109275 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag MK796_RS10375 Protein ID WP_000138934.1
Coordinates 2109287..2109580 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MK796_RS10350 (2104574) 2104574..2105932 - 1359 WP_000611468.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
MK796_RS10355 (2105947) 2105947..2107017 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
MK796_RS10360 (2107335) 2107335..2108537 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
MK796_RS10365 (2108801) 2108801..2108938 - 138 WP_000828354.1 Lmo0850 family protein -
MK796_RS10370 (2109066) 2109066..2109275 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
MK796_RS10375 (2109287) 2109287..2109580 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
MK796_RS10380 (2109746) 2109746..2111230 + 1485 WP_057504585.1 cardiolipin synthase -
MK796_RS10385 (2111258) 2111258..2111905 + 648 WP_001187610.1 HD domain-containing protein -
MK796_RS10390 (2112720) 2112720..2113592 - 873 WP_000725802.1 membrane protein insertase YidC -
MK796_RS10395 (2113678) 2113678..2114319 - 642 WP_000483147.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T237210 WP_000581792.1 NZ_CP092825:c2109275-2109066 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T237210 NZ_LR792683:375705-376091 [Kyrpidia spormannii]
ATGAAGACCCTTCTTGATACGCACGTCTTCCTGTGGTGGATCACCGATGATGGGCGGATGTCCAAACGTGCAAGAGCGAT
TATCCAAGATACAAGGAATGAACTGTATTTAAGTGCGGCGAGTGCCTGGGAGATCGCGATCAAAGCCGCCCTCGGCCGAA
TACGCGTATACGAAGATTTGGACCGGTTCATGACCCAGCAGATGAACGAAAACGGTATTGTGGATTTGCCCGTCGAGATC
CTCCATGCGCTCGGGGTCTATGGGCTTCCGGATTTGCACCGCGACCCGTTCGACCGCCTTTTGGTCGCCCAAGCCATACA
AGAAGGCATGCCCATCATCACCGCGGACGAGTGGATCAAGCGTTATGATGTTGAGACGATCTGGTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT237210 WP_000138934.1 NZ_CP092825:c2109580-2109287 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT237210 NZ_LR792683:375472-375708 [Kyrpidia spormannii]
GTGACCAAAGTGGTCAACGTCCACGAGGCAAAGACGCATTTTTCAAAACTATTGGCGCGTGTAGAAGTCGGGGAAGAGAT
CGTCATCGCGAAAGCGGGTAAACCCCTCGCCCGGCTCGTGCCTTATCGCGAACGGCCGACAAAGCGCGTACCGGGCACAG
CCAAAAGTCTAATTGTTGTCGGGGAAGATTTTGACGATCCGCTGCCGGAGTCGATTCAGAGGTTGTTCGAACGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References