Detailed information of TA system TA237209

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2089326..2089855
• Replicon: chromosome
• Accession: NZ_CP092825
• Organism: Staphylococcus aureus strain GY8

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: MK796_RS10280
• Protein ID: WP_000621175.1
• Coordinates: 2089326..2089688 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: MK796_RS10285
• Protein ID: WP_000948331.1
• Coordinates: 2089685..2089855 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MK796_RS10260 (2086305)	2086305..2087075	-	771	WP_001041107.1	RNA polymerase sigma factor SigB	-
MK796_RS10265 (2087050)	2087050..2087529	-	480	WP_001190825.1	anti-sigma B factor RsbW	-
MK796_RS10270 (2087531)	2087531..2087857	-	327	WP_001052491.1	anti-sigma factor antagonist	-
MK796_RS10275 (2087976)	2087976..2088977	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
MK796_RS10280 (2089326)	2089326..2089688	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
MK796_RS10285 (2089685)	2089685..2089855	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
MK796_RS10290 (2089940)	2089940..2091088	-	1149	WP_001280702.1	alanine racemase	-
MK796_RS10295 (2091154)	2091154..2091513	-	360	WP_000581194.1	holo-ACP synthase	-
MK796_RS10300 (2091517)	2091517..2092008	-	492	WP_001205915.1	PH domain-containing protein	-
MK796_RS10305 (2091995)	2091995..2093578	-	1584	WP_001294642.1	PH domain-containing protein	-
MK796_RS10310 (2093571)	2093571..2094050	-	480	WP_001287083.1	hypothetical protein	-
MK796_RS10315 (2094259)	2094259..2094819	-	561	WP_001092405.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T237209 WP_000621175.1 NZ_CP092825:c2089688-2089326 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T237209 NZ_LR792683:199918-200268 [Kyrpidia spormannii]
GTGAACATCAAGCGAGGGGATATTTTTTTTGCGAATCTATCCCCGGTGGTCGGTTCTGAACAAGGGGGCTTCCGGCCGGT
ATTGGTGATCCAAAACGATATCGGAAACCGGTTTAGCCCGACAGTCATCGTCGCGGCAATCACCGCCCAGATTCAGAAGG
CCAAGCTGCCCACCCACGTGGAGATTGATGCGAAAACCTACGGACTGGATCGGGATTCGGTCATCCTCCTGGAGCAGATT
CGCACCATTGATAAGCAGCGGTTGACGGATAAGATTACGCACCTGGACGATGAGATGATGAGCAAGGTCAACGAGTCGCT
CATGATCAGCCTGGGGTTGATCGATTTTTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT237209 WP_000948331.1 NZ_CP092825:c2089855-2089685 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT237209 NZ_LR792683:199615-199914 [Kyrpidia spormannii]
ATGGCGAGTGTCCCGGAGGTGCTTGGGTTGTCCGAGACAAAGCGGATTATGATTAGTGTTCCGAGTCACCTGCTCCAGGA
AGTCGACGGAATTGCAGAAAGAGAGAATTCCAATCGAAGCGAGGTCATTCGCCAAGCGATGAGACTGTATTTGGAAGAGC
GTAAAAAGGAACGCATTCGCGAGTTGATGCAGCGGGGTTATGTGGAGATGGCGAAGATTAACCTTTATATTGCGTCGGAG
GCGTTTTACGCCGAAGAGGAGGCGGGTTCGACCCTAGATCGACTAGTAAGCGGGGTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1